Resveratrol Capsules 100mg Taj Pharma

Resveratrol is part of a group of compounds called polyphenols. They’re thought to act like antioxidants, protecting the body against damage that can put you at higher risk for things like cancer and heart disease.

It’s in the skin of red grapes, but you can also find it in peanuts and berries.

Benefits

It’s gained a lot of attention for its reported anti-aging and disease-fighting powers. Still, it’s important to note that while experts agree that it does have potential, there’s still not enough data to confirm its effectiveness. Still, early research does suggest it might help protect you against:

Heart disease: It’s thought to help reduce inflammation, lower LDL or “bad” cholesterol, and make it more difficult for clots to form that can lead to a heart attack.

Cancer: It could limit the spread of cancer cells and start killing them.

Alzheimer’s: It may protect nerve cells from damage and fight the plaque buildup that can lead to the disease.

Diabetes: Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the blood sugar-lowering hormone insulin. The condition can lead to diabetes.

Researchers believe that resveratrol activates the SIRT1 gene. That gene is believed to protect the body against the effects of obesity and the diseases of aging.

Side Effects

So far, studies have not discovered any severe ones, even when resveratrol is taken in large doses.

However, these supplements might interact with blood thinners like warfarin (Coumadin), and NSAID medications like aspirin and ibuprofen. That may raise your chance of bleeding.

As with other supplements, the FDA doesn’t regulate resveratrol. That makes it difficult for consumers to know exactly what they’re getting or whether the product is effective. There also isn’t any specific dosage recommendation, and how much you should take can vary from supplement to supplement.

The dosages in most resveratrol supplements are typically much lower than the amounts that have been shown beneficial in research. Most supplements contain 250 to 500 milligrams. To get the dose used in some studies, people would have to consume 2 grams of resveratrol (2,000 milligrams) or more a day.

Adverse effects

In a year-long preliminary clinical trial in people with Alzheimer’s disease, the most frequent adverse effects were diarrhea, weight loss, and nausea. A 2018 review of resveratrol effects on blood pressure found that some people had increased frequency of bowel movements and loose stools, and one person taking a 1000 mg daily dose developed an itchy rash

Pharmacology

Pharmacodynamics

Resveratrol has been identified as a pan-assay interference compound, which produces positive results in many different laboratory assays. Its ability for varied interactions may be due to direct effects on cell membranes.

As of 2015, many specific biological targets for resveratrol had been identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at that time if any or all of these were responsible for the observed effects in cells and model organisms.^[23]

In vitro studies indicate resveratrol activates sirtuin 1,^[24] although this may be a downstream effect from its immediate biological target(s). It appears to signal through PGC-1α, thereby affecting mitochondria. In cells treated with resveratrol, an increase is observed in the action of MnSOD (SOD2) and in GPER activity. In vitro, resveratrol was shown to act as an agonist of Peroxisome proliferator-activated receptor gamma, a nuclear receptor under pharmacological research as a potential treatment for type 2 diabetes.

Pharmacokinetics

One way of administering resveratrol in humans may be buccal delivery by direct absorption through the saliva. However, the viability of a buccal delivery method is unlikely due to the low aqueous solubility of the molecule.The bioavailability of resveratrol is about 0.5% due to extensive hepatic glucuronidation and sulfation.

Metabolism

Resveratrol is extensively metabolized in the body, with the liver and lungs as the major sites of its metabolism.