The following doses have been studied in scientific research:
BY MOUTH:
For decline in memory and thinking skills that occurs normally with age: 1000-2000 mg of citicoline per day.
For a group of eye disorders that can lead to vision loss (glaucoma): 500-1600 mg per day.
For stroke: 500-2000 mg of citicoline per day starting within 24 hours of stroke.
CDP-Choline (Citicholine)
Citicoline is a brain chemical that occurs naturally in the body. As a medicine, it is taken by mouth as a supplement. In Japan and Europe, Citicoline was originally used as a prescription drug to help improve memory, thinking, and brain function in people who are healing from a stroke. It is primarily used as a dietary supplement.
Citicoline is taken by mouth, to help memory loss due to aging, improve vision in people with glaucoma, and help with recovery in stroke patients. It is also used for Alzheimer disease, Parkinson disease, bipolar disorder, lazy eye, and other conditions of the brain. But there is no good scientific research to support these other uses.
HEALTH BENEFITS:
Choline plays an important part in many processes in your body, including:
Cell structure It is needed to make fats that support the structural integrity of cell membranes.
Cell messaging It is involved in the production of compounds that act as cell messengers.
Fat transport and metabolism It is essential for making a substance required for removing cholesterol from your liver. Inadequate choline may result in fat and cholesterol buildup in your liver.
DNA synthesis Choline and other vitamins, such as B12 and folate, help with a process that’s important for DNA synthesis.
A healthy nervous system This nutrient is required to make acetylcholine, an important neurotransmitter. It’s involved in memory, muscle movement, regulating heartbeat and other basic functions.
Cancer Some research indicates that women who eat a lot of choline may have a lower risk of breast cancer
Mental Health Some evidence suggests choline may play a role in the development and treatment of certain mental health disorders. One large observational study linked lower blood levels to a higher risk of anxiety — but not depression). These levels are also used as an indicator for certain mood disorders, and choline supplements are sometimes used to treat bipolar disorder. One study found that choline therapy improved symptoms of mania in individuals diagnosed with bipolar disorder.
Memory and Brain Function Large observational studies link choline intake and blood levels to improved brain function, including better memory and processing.Supplementing with 1,000 mg per day led to improved short- and long-term verbal memory in adults aged 50–85 who had poor memory. In a 6-month study, giving phosphatidylcholine to people with early Alzheimer’s disease modestly improved memory in one small subgroup.
SAFETY RELATED INFORMATION:
Consuming too much choline has been associated with unpleasant and potentially harmful side effects.
These include drops in blood pressure, sweating, fishy body odor, diarrhea, nausea and vomiting.
The daily upper limit for adults is 3,500 mg per day. This is the highest level of intake that is unlikely to cause harm.
It is very unlikely that someone could ingest this amount from food alone. It would be almost impossible to reach this level without taking supplements in large doses.
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