Description

Turmeric Curcumin (Curcuma longa) 500 mg Capsules
120 Capsules
For Anti-oxidant support
Promotes Antioxidant Health
Helps Support Normal Immune Function
Anti-aging
Joint pain management
Pure, Natural, Organic
HERBAL SUPPLEMENT 

OUR PRODUCT:

• Dairy-free
• Gluten-free
• Non-GMO
• Soy-free

COMPOSITION
Each Capsule contains: Curcumin extract (Curcuma longa) 500mg

THERAPEUTIC INDICATION
For Anti-oxidant support
Helps Support Normal Immune Function
Anti-aging
Joint pain management

DOSAGE AND ADMINISTRATION
One to three 500 mg capsules daily with or without food is the most common regimen recommended. In one study, patients took one 500 mg capsule twice daily with or without food for 8 weeks for treatment of major depressive disorder. Powdered turmeric root has traditionally been used as a stimulant and carminative at dosages of 0.5 to 3 g/day. Dosages of 3 to 6 g/day have been investigated for protective effects against ulcers. Daily oral doses of curcumin 3,600 mg have been advocated for use in clinical trials but dosages of up to 8 g/day have been used in patients with advanced pancreatic cancer. A highly absorbable colloidal nanoparticle formulation has been used at 1,800 mg/day for memory improvement and reduction of amyloid deposition in non-demented adults. Higher doses are associated with adverse GI effects.

HISTORY
Turmeric, sometimes called Indian saffron or the golden spice, is a tall plant that grows in Asia and Central America. Curcumin is the active ingredient in turmeric, and it has powerful biological properties. Ayurvedic medicine, a traditional Indian system of treatment, recommends turmeric for a variety of health conditions. These include chronic pain and inflammation. Western medicine has begun to study turmeric as a pain reliever and a healing agent.

HEALTH BENEFITS:

1. As Anti-Inflammatory:
   Several studies suggest that turmeric has a property of reducing inflammation. This anti-inflammatory ability might reduce the aggravation that people with arthritis feel in their joints.
2. As Pain reliever:
   Many anecdotal experiences suggest that turmeric is a pain reliever. The spice is reputed to relieve arthritis pain as well. Studies seem to support turmeric for pain relief, with one noting that it seemed to work better with ibuprofen(NSAID’s) in people relieving pain with arthritis in their knees.
3. In improving Liver function:
   Turmeric has been getting attention recently because of its antioxidant abilities. The antioxidant effect of turmeric appears to be so powerful that it may stop your liver from being damaged by toxins. This could be good news for people who take strong drugs for diabetes or other health conditions that might hurt their liver with long-term use.
4. In Digestion:
   Turmeric can also play an important role in digesting that food. Because of its antioxidant and anti-inflammatory properties, turmeric can contribute to healthy digestion. It’s used in ayurvedic medicine as a digestive healing agent. It also helps patients with gut inflammation and gut permeability, two measures of your digestive efficiency. Turmeric is even being explored as a treatment for irritable bowel syndrome.

SAFETY RELATED INFORMATION
Interactions:
Agents with Antiplatelet Properties: Herbs (Anticoagulant/Antiplatelet Properties) may enhance the adverse/toxic effect of Agents with Antiplatelet Properties. Bleeding may occur. Consider therapy modification.

Anticoagulants: Herbs (Anticoagulant/Antiplatelet Properties) may enhance the adverse/toxic effect of Anticoagulants. Bleeding may occur. Consider therapy modification.

Herbs (Anticoagulant/Antiplatelet Properties): May enhance the adverse/toxic effect of other Herbs (Anticoagulant/Antiplatelet Properties). Bleeding may occur. Consider therapy modification.

Nonsteroidal Anti-Inflammatory Agents: Herbs (Anticoagulant/Antiplatelet Properties) may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. Bleeding may occur. Consider therapy modification.

Salicylates: Herbs (Anticoagulant/Antiplatelet Properties) may enhance the adverse/toxic effect of Salicylates. Bleeding may occur. Consider therapy modification.

Thrombolytic Agents: Herbs (Anticoagulant/Antiplatelet Properties) may enhance the adverse/toxic effect of Thrombolytic Agents. Bleeding may occur. Consider therapy modification.
C.longa significantly inhibited the formation of the dextromethorphan metabolites, dextrorphan (DOR) and 3-methoxymorphinan (3-MM), in a dose-dependent and linear fashion. Urine metabolic ratio of dextromethorphan:DOR was significantly increased, while the dextromethorphan:3-MM ratio was insignificantly increased. C. longa has great potential to inhibit CYP2D6 enzyme activities.

A case report noted a probable interaction between turmeric (2.5 g/day for 5 days) and the vitamin K antagonist fluindione that resulted in a sudden increase in a 56-year-old woman’s previously stabilized international normalized ratio (INR) from 2 or 3 up to 6.5. However, no clinical signs of bleeding were observed. No information was documented that identified this interaction as an INR lab interaction versus a pharmacological one.

A case report of probable interaction between turmeric (at least 15 spoonsful/day) and tacrolimus was reported in a 56-year-old male liver transplant patient. All other possible causes of elevated tacrolimus and acute kidney injury were ruled out. The interaction was attributed to likely interference of tacrolimus metabolism by turmeric via the P450 3A system, which led to acute calcineurin inhibitor nephrotoxicity. Data from animal studies regarding the potential for turmeric to affect the P450 system supported the conclusion.

Other interaction data
Some studies have reported insignificant pharmacokinetic drug interactions with natural products. Limited information as well as potentially high interpatient variability in clinical response warrants cautious interpretation and/or application of these data in practice.

A small pharmacokinetic interactions study in healthy volunteers who received curcuminoid 4 g 4 times daily for 2 days prior to oral administration of single doses of midazolam, flurbiprofen, and acetaminophen found no significant changes in pharmacokinetic parameters including C_max, area under the curve, and terminal half-life. Investigators selected these agents to probe cytochrome (CYP) 3a (midazolam), 2C9 (flurbiprofen), sulfotransfer, and UDP-glucuronosyltransferase (acetaminophen).

Adverse Reactions
Trials have generally reported few adverse reactions associated with turmeric or curcumin ingestion, even at the high dosages used in cancer trials. GI-related symptoms have been reported. Allergic contact dermatitis was reported in 2 patients after using curcumin-containing chlorhexidine solutions, and patch tests were positive for curcumin in both cases. A case of anaphylaxis after turmeric ingestion has been documented. Over a 3-day period, the patient experienced recurrent urticaria and angioedema that was unresponsive to treatment with epinephrine, antihistamines, and corticosteroids. Allergy testing for turmeric was positive. A review identified 3 studies (n = 121) and 10 case reports confirming allergenic potential of curcumin via patch and skin prick testing. A 2017 FDA Safety Alert documented 2 acute serious hypersensitivity cases resulting from the IV injection of a curcumin emulsion compounded with polyethylene glycol (PEG) 40 castor oil. The latter is an ungraded product that is not suitable for human consumption and is known to cause hypersensitivity reactions. Both patients had a positive history of allergies; 1 case was fatal. The safety profile of curcumin administered by the IV route has not been established. The FDA recommendation was for the recall of all unexpired products containing the ungraded PEG 40 castor oil by the compounding agent, ImprimisRx.

Turmeric contains relatively high concentrations of oxalate, and increased levels of urinary oxalate excretion have been demonstrated. Although the risk of kidney stone formation may be increased in susceptible individuals, reports of kidney problems are lacking. The addition of curcumin to the diets of mice induced iron-deficiency anemia, including a decline in serum iron, decreased hematocrit, decreased transferrin saturation, and appearance of hypochromic RBCs. Curcumin also decreased iron levels in the bone marrow and spleen.

Data collected between 2004 and 2013 among 8 US centers in the Drug-induced Liver Injury Network revealed 15.5% (130) of hepatotoxicity cases was caused by herbals and dietary supplements whereas 85% (709) were related to medications. Of the 130 related cases of liver injury related to supplements, 65% were from non-bodybuilding supplements and occurred most often in Hispanic/Latinos compared to non-Hispanic whites and non-Hispanic blacks. Liver transplant was also more frequent with toxicity from non-bodybuilding supplements (13%) than with conventional medications (3%) (P<0.001). Overall, the number of severe liver injury cases was significantly higher from supplements than conventional medications (P=0.02). Of the 217 supplement products implicated in liver injury, turmeric was among the 22% (116) of the single-ingredient products.

Toxicology
Evaluation of mice treated with short- and long-term C. longa ethanolic extracts of 100 mg/kg/day for 90 days found no serious adverse reactions. Weight was not affected by long-term treatment; however, changes in heart and lung weight were reported, and white and red blood cell levels were reduced. The oral median lethal dose (LD₅₀) of curcumin in rats and mice was higher than 2,000 mg/kg body weight. No clinical ophthalmic, body weight, feed consumption, or organ weight changes were documented in a 90-day toxicity study in rats. Furthermore, no adverse effects from the toxicity study were noted on hematology, serum chemistry, and urinalysis.

Pregnancy / Lactation
Avoid use during pregnancy and lactation because potential emmenagogue and abortifacient effects have been documented. Estrogenic and antiandrogenic effects are documented in animal models. An extract of C. longa had a contraceptive effect in male rats. A reduction in sperm motility was observed in rats receiving turmeric 500 mg/kg/day as an aqueous or alcoholic extract.

MANUFACTURED BY:
TAJ PHARMACEUTICALS LTD.
Mumbai, India
Unit No. 214.Old Bake House,
Maharashtra chambers of  Commerce Lane,Fort,
Mumbai – 400001
at:Gujarat, INDIA.

Customer Service and Product Inquiries:
1-800-TRY-FIRST (1-800-222-434 & 1-800-222-825)
Monday through Saturday 9:00 a.m. to 7:00 p.m. EST
E-mail: tajgroup@tajpharma.com