Vasopressin Injection USP Synthetic 20 Units/1ml (Trazissin)

Vasopressin Injection USP Synthetic 20 Units/1ml (Trazissin) Technical Specification:

GENERIC NAME OF THE MEDICINAL PRODUCT:

• Vasopressin Injection USP Synthetic 20Units/1ml (Trazissin)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

• Vasopressin Injection USP Synthetic 20Units/1ml
  Each ml contains:
  Vasopressin USP………………………………………20Units
  Sodium Chloride USP………………………………9mg
  Chlorobutanol USP………………………………….0.5%w/v
  (as preservative)
  Water for Injection USP………………………….q.s

THERAPEUTIC INDICATIONS:

Vasopressin injection is used to control the frequent urination, increased thirst, and loss of water caused by diabetes insipidus. It is also used to prevent and treat abdominal or stomach distension that occurs after surgery. It is also used in abdominal or stomach roentgenography. It is a hormone produced in the body and acts on the kidneys to reduce the flow of urine. It is also used to increase blood pressure in adults with vasodilatory shock (eg, post-cardiotomy, sepsis) who remain to have low blood pressure after receiving fluids and medicines.

DIRECTION OF USE:

For Intravenous infusion or Intramuscular Intravenous or Subcutaneous use only.
Use only after reading the directions on pack insert.

CAUTION & WARNING:

CAUTION: Must be diluted prior to use.
This injection should not be used if it contains visible particulate matter.
Discard unused portion.

Warning: To be sold by retail on the prescription of an Oncologist/Specialist only.

STORAGE & DOSAGE:

Storage: Store in a refrigerator at 2°C to 8°C (36°F to 46°F).
Do not freeze.
Protect from light.
Keep all medicines out of reach of children.

Dosage: As directed by the Physician.

Note:  

After initial entry into the vial, remaining contents must be refrigerated and used within 30 days. (Multi dose vial)
After initial entry in to the vial, the remaining contents must be used within 48 hours. (Single dose vial)
Discard prepared infusion solutions after 18 hours at room temperature or 24 hours refrigerated.

Why Taj Pharamceuticals?

Taj Pharmaceuticals has emerged as a beacon of unwavering commitment to healthcare excellence, and this commitment extends prominently to our provision of Vasopressin Injection, a medication with critical applications in various medical scenarios. What sets us apart is our steadfast dedication to principles of quality, innovation, and, above all, the well-being of patients. Quality serves as the bedrock of Taj Pharmaceuticals. Our pledge to quality is not just a promise but a way of life. Each vial of Vasopressin Injection undergoes meticulous scrutiny through stringent quality control measures to ensure it conforms to the highest standards of safety and efficacy. Our pharmaceutical legacy thrives on this unwavering commitment to maintaining exceptional quality. Innovation is in our DNA. Taj Pharmaceuticals doesn’t just follow industry trends; we set them. We are pioneers in healthcare innovation, perpetually seeking ways to elevate medical solutions to enhance the well-being of individuals. Vasopressin Injection exemplifies our dedication to pushing the boundaries of innovation within the pharmaceutical industry. When you choose Taj Pharmaceuticals for Vasopressin Injection, you’re not merely selecting a medication; you’re forging a partnership in your journey towards health and recovery. Your well-being takes precedence, and we take immense pride in being a dependable source of this vital medication, both for healthcare providers and patients alike. Our vision extends beyond borders. We firmly believe that access to quality healthcare should transcend geographical constraints. Taj Pharmaceuticals’ global reach ensures that individuals across the world can access high-quality Vasopressin Injection. We are committed to bridging gaps in healthcare accessibility, ensuring that quality healthcare is a right, not a privilege. In your pursuit of health and well-being, Taj Pharmaceuticals stands as your steadfast ally. Place your trust in our legacy of excellence, and let us be your partner in the journey towards improved health and vitality. Your health is our mission, and we are unwavering in our dedication and integrity as we serve you.

What is Vasopressin Injection and its uses:

Vasopressin, also known as antidiuretic hormone (ADH), is a vital hormone naturally produced by the body to regulate water balance. However, in medical settings, synthetic Vasopressin Injection is employed for specific purposes. One of its primary uses is in addressing severe hypotension (low blood pressure) and shock situations when conventional measures like fluid replacement fail to maintain adequate blood pressure. By constricting blood vessels, Vasopressin Injection helps elevate blood pressure and enhance blood flow to vital organs, a critical intervention in life-threatening situations. Another significant application is in controlling acute bleeding from esophageal varices, a condition characterized by swollen veins in the esophagus. Vasopressin reduces blood flow to these veins, thereby lowering the risk of bleeding. In cases of diabetes insipidus, where the body inadequately produces vasopressin, this synthetic hormone serves as a replacement therapy. It regulates water balance, reducing excessive urination and thirst. In pediatric medicine, Vasopressin may be used to address nocturnal enuresis, or bedwetting, by decreasing nighttime urine production. Additionally, during cardiopulmonary resuscitation (CPR), it can be an alternative to epinephrine, enhancing blood flow to the heart and brain. Finally, in select situations, Vasopressin Injection may be employed to manage electrolyte imbalances. However, the use of Vasopressin Injection necessitates close monitoring by healthcare professionals due to its potent effects on blood pressure and fluid balance. The specific dosage and administration route depend on the medical condition being treated. Typically administered intravenously in clinical settings, Vasopressin Injection demands precise control and monitoring. Therefore, it should only be used under the guidance and supervision of a healthcare provider who can assess its suitability for a particular condition and monitor its effects closely.

How do Vasopressin Injection work?

Vasopressin Injection, a synthetic form of the hormone vasopressin (ADH), operates through several intricate physiological mechanisms to regulate water balance and address specific medical conditions. One of its primary actions is vasoconstriction, where it binds to receptors on smooth muscle cells in blood vessels, causing them to contract. This narrowing of blood vessels, known as vasoconstriction, leads to increased peripheral resistance and higher blood pressure. This effect is particularly critical in scenarios of severe hypotension and shock, where Vasopressin helps improve blood flow to vital organs by elevating blood pressure. Another key role of Vasopressin lies in its ability to regulate water reabsorption in the kidneys. When Vasopressin levels rise in response to low blood volume or increased blood osmolarity, it signals the kidneys to conserve water. Specifically, Vasopressin acts on the collecting ducts within the kidneys, making them more permeable to water. This action allows the body to reabsorb water from the urine, reducing urine output and conserving vital fluids. Reducing urine output is particularly beneficial in conditions such as diabetes insipidus, where the body’s natural production of Vasopressin is insufficient. By promoting water reabsorption, Vasopressin helps manage excessive urination and the associated risk of dehydration. Additionally, Vasopressin has applications in managing acute bleeding situations, such as bleeding from esophageal varices. It achieves this by constricting blood vessels in the vicinity of the bleeding site, effectively reducing blood flow to the affected area and aiding in the control of bleeding. In the context of cardiopulmonary resuscitation (CPR), Vasopressin may serve as an alternative to epinephrine. Its ability to increase blood pressure and enhance coronary artery perfusion contributes to improved circulation during life-saving interventions. Vasopressin Injection exerts its effects through vasoconstriction and the regulation of water reabsorption in the kidneys. These mechanisms are pivotal in addressing various medical conditions, from managing hypotension and shock to controlling diabetes insipidus and effectively managing acute bleeding episodes.

Benefits of Vasopressin Injection:

Vasopressin Injection serves as a vital medication with a range of benefits in various medical scenarios. One of its foremost advantages lies in the treatment of severe hypotension and shock, where it can rapidly elevate blood pressure, ensuring improved blood flow to critical organs. This property makes it a crucial intervention in life-threatening situations, potentially saving lives.

In cases of gastrointestinal bleeding, particularly from esophageal varices common in liver disease, Vasopressin’s ability to constrict blood vessels at the bleeding site is invaluable. It aids in halting bleeding and promoting patient stability.

For individuals suffering from diabetes insipidus, characterized by excessive thirst and urination due to inadequate natural vasopressin production, Vasopressin Injection offers relief. By regulating water balance, it reduces excessive urination and alleviates thirst.

In pediatric medicine, Vasopressin may be prescribed to manage nocturnal enuresis (bedwetting), improving the sleep quality of children.

During cardiopulmonary resuscitation (CPR), Vasopressin can be an alternative to epinephrine, contributing to enhanced blood flow to the heart and brain, potentially improving outcomes during resuscitation efforts.

Side Effects of Vasopressin Injection:

However, Vasopressin Injection also comes with potential side effects that necessitate careful monitoring. One significant side effect is a rapid increase in blood pressure, which can lead to hypertension. Close monitoring is essential to manage blood pressure effectively during treatment.

Vasopressin’s vasoconstrictive effects can reduce blood flow to the extremities, potentially causing cold or pale fingers and toes.

It may influence heart rhythm and could lead to arrhythmias, including ventricular arrhythmias, underscoring the need for vigilant cardiac monitoring.

Gastrointestinal symptoms like nausea, vomiting, and abdominal cramps are common with Vasopressin use.

Excessive Vasopressin administration can result in water retention, potentially causing edema and electrolyte imbalances.

While allergic reactions to Vasopressin are rare, they can manifest as hives, rash, itching, or facial swelling, necessitating immediate medical attention.

In conclusion, Vasopressin Injection offers critical benefits in managing various medical conditions, but its potent effects also entail potential side effects. Healthcare professionals must carefully weigh these factors, closely monitoring patients receiving Vasopressin to optimize its therapeutic benefits while minimizing any adverse effects. Patient safety remains paramount in the administration of this powerful medication.

Frequently Asked Questions About Vasopressin Injection:

1. What is Vasopressin Injection used for?

Vasopressin Injection is primarily used to treat severe hypotension and shock, control acute bleeding from esophageal varices, manage diabetes insipidus, address bedwetting (nocturnal enuresis) in pediatric patients, and serve as an alternative to epinephrine during cardiopulmonary resuscitation (CPR).

2. How does Vasopressin work?

Vasopressin functions by constricting blood vessels (vasoconstriction), raising blood pressure, and enhancing blood flow to vital organs. It also regulates water reabsorption in the kidneys, reducing urine output and conserving fluids.

3. Is Vasopressin the same as ADH (antidiuretic hormone)?

Yes, Vasopressin is often referred to as antidiuretic hormone (ADH). Both terms describe the same hormone produced naturally by the body to regulate water balance.

4. What are the side effects of Vasopressin Injection?

Common side effects include hypertension, decreased blood flow to extremities, arrhythmias, gastrointestinal symptoms (nausea, vomiting, abdominal cramps), water retention, and, rarely, allergic reactions. These side effects should be closely monitored by healthcare professionals.

5. How is Vasopressin Injection administered?

Vasopressin is typically administered intravenously (IV) in clinical settings to ensure precise control and monitoring. Dosage and administration route vary depending on the specific medical condition being treated.

6. Can Vasopressin Injection be used during pregnancy and breastfeeding?

The use of Vasopressin during pregnancy and breastfeeding should be carefully evaluated by a healthcare provider, weighing the potential benefits against potential risks to both the mother and the baby.

7. Are there any drug interactions with Vasopressin Injection?

Vasopressin may interact with certain medications, including diuretics and drugs that affect blood pressure. It’s crucial to inform your healthcare provider about all medications you are taking to avoid potential interactions.

8. What precautions should be taken when using Vasopressin Injection?

Patients receiving Vasopressin should be closely monitored for blood pressure, heart rhythm, and fluid balance. Healthcare professionals should adjust dosage and treatment as needed to ensure patient safety.

9. Can Vasopressin be used outside of a hospital setting?

Vasopressin is a potent medication with potential risks and side effects. Its use outside of a hospital or medical facility should only occur under the direct guidance and supervision of a qualified healthcare provider in specific emergency situations.

10. Is Vasopressin available in generic form?

Yes, Vasopressin is available in generic form as well as under various brand names. Generic formulations provide a cost-effective alternative to the brand-name versions while maintaining therapeutic efficacy.

As Vasopressin Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Vasopressin Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Vasopressin Injection Regulatory Documents:

• Certificate of Analysis (COA)
• Method of Analysis (MOA)
• Stability Data (Accelerated stability / Long-term stability / Zone 4b)
• CTD Dossier / ACTD Dossiers / eCTD Dossiers
• Certificate of Pharmaceuticals Product (COPP)
• Free Sale Certificate (FSC)

Contact the most reliable manufacturer of  Vasopressin Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274