Succinylcholine Chloride Injection USP 100mg/2ml

Succinylcholine Chloride Injection USP 100mg/2ml (50mg/ml) Technical Specification:

GENERIC NAME OF MEDICINAL PRODUCT:

• Succinylcholine Chloride Injection USP 100mg/2ml

QUALITATIVE AND QUANTITATIVE COMPOSITION:

• Succinylcholine Chloride Injection USP 100mg/2ml
  Each ml contains:
  Succinylcholine Chloride USP
  Anhydrous Succinylcholine Chloride………………………….50mg
  Benzyl Alcohol BP (as preservative) ……………1.5 % v/v
  Water for Injections USP………………………………….q.s. 

THERAPEUTIC INDICATION:

Succinylcholine chloride is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

CAUTION & WARNING:

CAUTION:

• CAUTION: If any foreign particle, breakage, or leakage is visible do not use it and return for a replacement.
• WARNING: NOT FOR USE IN NEWBORNS. 
• The paralyzing agent may cause paralysis of respiratory muscles as well leading to Respiratory arrest.
  Facilities must be immediately available for Artificial Respiration.
  KEEP OUT OF REACH AND SIGHT OF CHILDREN.

WARNING: Not to be sold by retail without the prescription of a Registered Medical Practitioner.

STORAGE & DOSAGE:

Storage: Store between 2° to 8°C. Protected from light. Do not freeze.
Dosage: As directed by the Physician.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals is your dependable supplier of Succinylcholine Chloride Injection, an essential medication used in anesthesia for muscle relaxation during surgeries. With our unwavering commitment to pharmaceutical excellence and stringent quality assurance, we stand as a trusted provider of healthcare solutions. Our dedication to patient well-being ensures that Succinylcholine Chloride Injection meets the highest international standards of safety and efficacy. We prioritize accessibility to essential medications, ensuring that healthcare providers have access to reliable neuromuscular blocking agents when needed most. At Taj Pharmaceuticals, we understand the critical role that Succinylcholine Chloride plays in anesthesia and surgical procedures. Our commitment to quality and safety drives us to provide high-quality medications that healthcare professionals can rely on for precise and controlled muscle relaxation. Choose Taj Pharmaceuticals for Succinylcholine Chloride Injection, and experience pharmaceutical expertise that prioritizes your health and the well-being of your patients. We are dedicated to contributing to improved healthcare outcomes by delivering quality medications that make a difference in surgical procedures and patient care. Trust Taj Pharmaceuticals for all your pharmaceutical needs and partner with us in your journey to better health.

What is Succinylcholine Chloride Injection and its uses?

Succinylcholine Chloride Injection is a medication used primarily in anesthesia and surgery to induce muscle relaxation, a state known as neuromuscular blockade. It has specific uses and applications in medical settings:

• Facilitating Endotracheal Intubation: One of the primary uses of Succinylcholine is to facilitate the insertion of an endotracheal tube during general anesthesia. It paralyzes the muscles of the body, including the respiratory muscles, which allows the anesthesiologist or surgeon to insert a breathing tube into the patient’s airway more easily.
• Improving Surgical Conditions: Succinylcholine can be administered to achieve profound muscle relaxation during surgery. This is especially important in procedures where muscle contractions could interfere with the surgical field or create complications.
• Reducing the Risk of Aspiration: In surgeries involving the gastrointestinal tract, such as abdominal or gastrointestinal procedures, Succinylcholine can help prevent regurgitation and aspiration of stomach contents by relaxing the lower esophageal sphincter.
• Facilitating Mechanical Ventilation: In intensive care units (ICUs) and emergency departments, Succinylcholine may be used to provide temporary paralysis in patients requiring mechanical ventilation or those with acute respiratory distress.
• Diagnostic Procedures: Succinylcholine can be used during certain diagnostic procedures, such as bronchoscopy or imaging studies, where muscle relaxation is necessary for safe and effective examination.

It’s important to note that Succinylcholine is a potent neuromuscular blocking agent, and its use requires careful monitoring and administration by trained healthcare professionals, typically anesthesiologists or anesthesia providers. The effects of Succinylcholine are temporary, and the patient’s neuromuscular function typically recovers once the medication wears off or is reversed with appropriate agents.

How does Succinylcholine Chloride Injection work?

Succinylcholine Chloride Injection works as a neuromuscular blocking agent that produces a rapid and temporary paralysis of skeletal muscles. Its mechanism of action involves interfering with neuromuscular transmission at the neuromuscular junction. Here’s how it works:

• Normal Neuromuscular Transmission: In normal muscle function, nerve impulses (action potentials) travel down motor neurons and reach the neuromuscular junction. This is the point where the motor neuron communicates with the muscle fiber.
• Release of Acetylcholine: At the neuromuscular junction, the arrival of the nerve impulse leads to the release of a neurotransmitter called acetylcholine (ACh) from the nerve terminal into the synaptic cleft (the tiny gap between the nerve and muscle fiber).
• Activation of Muscle Contraction: Acetylcholine binds to receptors on the muscle fiber’s membrane (sarcolemma), leading to the activation of muscle contraction. This involves a series of events that ultimately result in the muscle fiber contracting.
• Role of Cholinesterase: To ensure that muscle contraction is brief and well controlled, acetylcholine must be rapidly broken down in the synaptic cleft. An enzyme called acetylcholinesterase plays a crucial role in this process.
• Action of Succinylcholine: Succinylcholine, when administered intravenously, acts as a depolarizing neuromuscular blocking agent. It mimics the action of acetylcholine and binds to the same receptors on the muscle fiber’s membrane. However, unlike acetylcholine, Succinylcholine is resistant to degradation by acetylcholinesterase.
• Persistent Muscle Depolarization: When Succinylcholine binds to the receptors, it causes a persistent and prolonged depolarization of the muscle fiber membrane. This leads to a state of muscle paralysis, preventing normal muscle contractions.
• Temporary Paralysis: The paralysis induced by Succinylcholine is temporary and typically lasts for a few minutes. After this period, the medication is metabolized and eliminated from the body, and neuromuscular function gradually returns.
• Reversibility: The effects of Succinylcholine are reversible, and neuromuscular function can be restored more rapidly by the administration of cholinesterase inhibitors, such as neostigmine and atropine. These medications help break down the Succinylcholine molecules and restore normal neuromuscular transmission.

Succinylcholine is used in anesthesia to achieve muscle relaxation during surgical procedures, particularly those requiring endotracheal intubation or where muscle contractions could interfere with the surgical field. Its rapid onset and temporary duration of action make it a valuable tool in medical settings where precise control of muscle function is essential.

Benefits of Succinylcholine Chloride Injection:

• Rapid Onset: Succinylcholine is known for its extremely rapid onset of action, typically taking effect within seconds of intravenous administration. This quick onset is crucial in situations where immediate muscle relaxation is needed.
• Short Duration: The effects of Succinylcholine are relatively short-lived, lasting for only a few minutes. This allows for precise control of muscle relaxation during surgical procedures.
• Facilitates Endotracheal Intubation: It is commonly used to facilitate the insertion of an endotracheal tube during general anesthesia. The muscle relaxation it provides makes intubation smoother and reduces the risk of complications.
• Improved Surgical Conditions: Succinylcholine ensures optimal surgical conditions by inducing profound muscle relaxation. This is particularly important in procedures where muscle contractions could interfere with the surgical field.
• Quick Recovery: Since the effects are short-lived, patients usually regain muscle function and consciousness rapidly after the medication’s administration is stopped.

Side Effects of Succinylcholine Chloride Injection:

• Muscle Pain: Many patients experience muscle pain or soreness, known as myalgia, after the effects of Succinylcholine wear off. This is typically mild and temporary.
• Increased Intracranial Pressure: Succinylcholine can lead to a transient increase in intracranial pressure, which may be a concern in patients with head injuries or intracranial conditions.
• Hyperkalemia: In rare cases, Succinylcholine administration can cause a rapid release of potassium from muscle cells, potentially leading to elevated blood potassium levels (hyperkalemia). This can be particularly dangerous in patients with certain medical conditions, such as burns, trauma, or neuromuscular disorders.
• Malignant Hyperthermia: Although rare, Succinylcholine has been associated with a condition called malignant hyperthermia, which involves a dangerous increase in body temperature and muscle rigidity. This is typically a genetic susceptibility, and it requires immediate treatment.
• Allergic Reactions: While uncommon, allergic reactions to Succinylcholine can occur and may include rash, itching, or swelling.
• Increased Intraocular Pressure: Succinylcholine can temporarily increase intraocular pressure, which may be of concern in patients with certain eye conditions.
• Transient Bradycardia or Tachycardia: Changes in heart rate, such as bradycardia (slow heart rate) or tachycardia (fast heart rate), may occur following Succinylcholine administration.
• Respiratory Depression: Succinylcholine can cause respiratory depression, especially if it is used inappropriately or in high doses. Adequate ventilation and oxygenation must be maintained during its use.
• Postoperative Myalgia: Some patients may experience muscle pain or stiffness in the postoperative period.

It’s important to emphasize that Succinylcholine should be administered by trained healthcare professionals, typically anesthesiologists or anesthesia providers, who are experienced in its use and are prepared to manage potential complications. The choice to use Succinylcholine is made based on the specific patient’s needs, the nature of the surgical procedure, and a careful assessment of the risks and benefits. Patients should discuss any concerns or questions with their healthcare providers before undergoing procedures involving Succinylcholine.

Frequently Asked Questions About Succinylcholine Chloride Injection:

Certainly, here are some frequently asked questions (FAQs) about Succinylcholine Chloride Injection:

1. What is Succinylcholine Chloride Injection used for?

Succinylcholine is primarily used as a neuromuscular blocking agent in anesthesia to induce muscle relaxation, particularly for facilitating endotracheal intubation during surgery.

2. How quickly does Succinylcholine Chloride take effect?

Succinylcholine is known for its rapid onset of action, typically taking effect within seconds after intravenous administration.

3. How long does the muscle relaxation last with Succinylcholine?

The effects of Succinylcholine are relatively shortlived, typically lasting for a few minutes. Muscle function and consciousness usually return quickly after administration is stopped.

4. Are there any side effects of Succinylcholine Chloride Injection?

Yes, Succinylcholine can have side effects, including muscle pain, increased intracranial pressure, hyperkalemia (elevated blood potassium levels), and the potential for malignant hyperthermia, among others. The risk of side effects depends on individual factors and medical conditions.

5. Is Succinylcholine safe for all patients?

No, Succinylcholine may not be suitable for all patients. It should be used with caution in individuals with certain medical conditions, and the decision to use it is based on a careful assessment of the patient’s health and the nature of the procedure.

6. Can Succinylcholine be reversed or its effects be terminated?

The effects of Succinylcholine are temporary and can be terminated by allowing the medication to wear off or by using medications that reverse its effects, such as cholinesterase inhibitors like neostigmine.

7. What precautions are taken to prevent complications with Succinylcholine use?

Healthcare providers closely monitor patients during and after Succinylcholine administration to detect and manage potential complications promptly. Adequate ventilation and oxygenation are maintained to prevent respiratory issues.

8. Is there an alternative to Succinylcholine for muscle relaxation during surgery?

Yes, there are alternative neuromuscular blocking agents available, such as rocuronium or vecuronium, that have a longer duration of action and may be preferred in some cases.

9. Can Succinylcholine be used in pediatric patients?

Yes, Succinylcholine can be used in pediatric patients, but the dosage is adjusted based on the child’s weight and age.

10. What should patients discuss with their healthcare providers before undergoing surgery involving Succinylcholine?

Patients should inform their healthcare providers of any medical conditions, allergies, or medications they are taking. They should also discuss any concerns or questions they have about the use of Succinylcholine during their procedure.

It’s essential for patients to have open communication with their healthcare providers and anesthesia team to ensure safe and effective use of Succinylcholine or any other medications during surgery or medical procedures.

As Succinylcholine Chloride Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Succinylcholine Chloride Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Succinylcholine Chloride Injection Regulatory Documents:

• Certificate of Analysis (COA)
• Method of Analysis (MOA)
• Stability Data (Accelerated stability / Long-term stability / Zone 4b)
• CTD Dossier / ACTD Dossiers / eCTD Dossiers
• Certificate of Pharmaceuticals Product (COPP)
• Free Sale Certificate (FSC)

Contact the most reliable manufacturer of Succinylcholine Chloride Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593