Rifampicin Capsules USP 300mg Technical Specification:

Product Name:Rifampicin Capsules USP 300mg
Brand Name:Generic
Strength:300mg, 150mg
Dosage Form:Capsules (Hard-gelatin)
Route of Administration:Via Oral Route
Packing:10s, 30s, 100s, 500s
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Anti-tuberculosis
Indication: Rifampin is used together with other medicines to treat tuberculosis (TB) in many different parts of the body. It is also used by patients who have a meningitis bacteria in their nose or throat who do not show symptoms of the infection to prevent the spread of the bacteria to other patients
Storage:Store at 20° to 25°C (68° to 77°F)

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Rifampicin Capsules USP 300mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Rifampicin Capsules USP 300mg
    Each hard gelatin Capsule contains:
    Rifampicin USP………………………..300mg
    Excipients………………………………….q.s.

THERAPEUTIC INDICATIONS:

Rifampin is used together with other medicines to treat tuberculosis (TB) in many different parts of the body. It is also used by patients who have a meningitis bacteria in their nose or throat who do not show symptoms of the infection to prevent the spread of the bacteria to other patients. 

CAUTION & WARNING:

CAUTION:  SWALLOW WHOLE DO NOT CHEW OR CRUSH
Read enclosed leaflet before use.
Keep medicine out of reach of children. 

Warning:  To be sold by retail on the prescription of a Registered Medical Practitioner only. 

STORAGE & DOSAGE:

Storage: Store at 20° to 25°C (68° to 77°F)

Dosage: As directed by the Physician. 

Attach dispensing label as per end country.

Why Taj Pharmaceuticals?

Choose Taj Pharma for Rifampicin Capsules USP, your partner in the fight against tuberculosis and bacterial infections. Taj Pharma’s Rifampicin Capsules USP are manufactured to the highest standards, ensuring consistent quality and efficacy. Our decades of experience and unwavering dedication to pharmaceutical excellence make us the preferred choice for healthcare professionals and patients alike. Rifampicin is a vital component in the treatment of tuberculosis (TB) and various other serious bacterial infections. Taj Pharma’s Rifampicin Capsules USP offers a dependable solution, backed by rigorous quality control measures and a commitment to patient well-being. Trust Taj Pharma for the reliable supply of this essential medication, so you can focus on achieving optimal health outcomes.

What is Rifampicin Capsules USP and its use?

Rifampicin Capsules USP (United States Pharmacopeia) is a medication commonly prescribed for the treatment of various bacterial infections, with its most notable use being in the treatment of tuberculosis (TB). Rifampicin is a broad-spectrum antibiotic that is highly effective against certain types of bacteria, particularly Mycobacterium tuberculosis, which causes TB. Here’s more information about Rifampicin Capsules USP and its uses:

Uses of Rifampicin Capsules USP:

  • Treatment of Tuberculosis (TB): Rifampicin is a cornerstone drug in the standard treatment regimen for both active TB and latent TB infection. It is often used in combination with other antibiotics, such as isoniazid, pyrazinamide, and ethambutol, to effectively treat TB and prevent its spread.
  • Treatment of Other Mycobacterial Infections: Rifampicin may also be used to treat infections caused by other mycobacteria, such as Mycobacterium avium complex (MAC) infections, including in individuals with compromised immune systems.
  • Leprosy: Rifampicin can be part of the multidrug therapy used to treat leprosy (Hansen’s disease).
  • Brucellosis: In some cases, Rifampicin may be used in combination with other antibiotics to treat brucellosis, a bacterial infection often transmitted from animals to humans.
  • Meningococcal Carriers: Rifampicin can be used to eradicate meningococcal bacteria from the nasopharynx in individuals who are carriers of Neisseria meningitidis.

It’s important to note that Rifampicin is typically not used to treat common respiratory infections like the common cold or flu. Additionally, it should only be used under the guidance of a healthcare professional, as improper use or incomplete treatment can contribute to antibiotic resistance.

Rifampicin works by inhibiting the activity of an enzyme called RNA polymerase, which is essential for the synthesis of RNA in bacteria. By disrupting this process, Rifampicin effectively kills or inhibits the growth of susceptible bacteria.

How does Rifampicin Capsules USP work?

Rifampicin Capsules USP work as an antibiotic, primarily used to treat bacterial infections, with its most notable application being the treatment of tuberculosis (TB). Rifampicin is effective against a wide range of bacteria, particularly Mycobacterium tuberculosis, the bacterium responsible for TB. Here’s how Rifampicin works:

  • Inhibition of RNA Synthesis: Rifampicin targets a key bacterial enzyme called RNA polymerase. RNA polymerase is responsible for synthesizing RNA (ribonucleic acid), a crucial step in the replication and transcription of genetic information in bacteria.
  • Binding to RNA Polymerase: Rifampicin specifically binds to the beta subunit of bacterial RNA polymerase. This binding is highly selective for the bacterial enzyme and has little affinity for human RNA polymerase.
  • Blockage of RNA Synthesis: By binding to bacterial RNA polymerase, Rifampicin effectively inhibits its activity. This inhibition leads to the disruption of RNA synthesis in the bacterial cell. RNA is essential for protein synthesis and other vital cellular processes in bacteria.
  • Cellular Dysfunction: As RNA synthesis is crucial for bacterial growth and replication, the interference caused by Rifampicin leads to the dysfunction of essential cellular processes in the bacterium.
  • Bacterial Death or Growth Inhibition: The disruption of RNA synthesis ultimately results in the death of susceptible bacteria or, at the very least, a significant inhibition of their growth and multiplication.
  • Antibacterial Effect: Rifampicin’s antibacterial effect is broad-spectrum, meaning it is effective against various types of bacteria, not just Mycobacterium tuberculosis. It can be used to treat other bacterial infections, including those caused by Staphylococcus, Streptococcus, Neisseria, and Haemophilus species, among others.

It’s important to note that Rifampicin is typically used in combination with other antibiotics for the treatment of TB to prevent the development of antibiotic resistance. The use of multiple drugs in combination therapy helps to target the bacterium more effectively and reduces the likelihood of resistant strains emerging.

Rifampicin’s unique mechanism of action and broad-spectrum activity make it a valuable tool in the treatment of bacterial infections, particularly mycobacterial infections like TB. However, like all antibiotics, their use should be guided by a healthcare professional to ensure appropriate dosing and to minimize the risk of side effects and resistance.

Benefits and Side Effects of Rifampicin Capsules USP:

Rifampicin Capsules USP have several benefits in treating bacterial infections, particularly tuberculosis (TB), but they can also be associated with various side effects. It’s important to note that the benefits should outweigh the potential side effects, and Rifampicin should be used under the guidance of a healthcare professional. Here are the benefits and potential side effects:

Benefits:

  • Effective Treatment of TB: Rifampicin is one of the key antibiotics used in the treatment of tuberculosis. It is highly effective against Mycobacterium tuberculosis, the bacterium responsible for TB, and is a crucial component of combination therapy to treat both drug-susceptible and drug-resistant TB.
  • Broad-Spectrum Antibiotic: Rifampicin is effective against a wide range of bacteria, making it useful in treating various bacterial infections beyond TB, including infections caused by Staphylococcus, Streptococcus, Neisseria, and Haemophilus species.
  • Combination Therapy: Rifampicin is often used in combination with other antibiotics, which helps prevent the development of antibiotic resistance and increases the overall efficacy of treatment.
  • Shorter Treatment Duration: In many cases, the inclusion of Rifampicin in TB treatment regimens can lead to shorter treatment durations, improving patient compliance and reducing the risk of relapse.
  • Prophylaxis: Rifampicin can also be used prophylactically in certain situations, such as to prevent the spread of TB within households or to protect individuals exposed to TB.

Side Effects:

  • Gastrointestinal Distress: Common side effects of Rifampicin can include nausea, vomiting, diarrhea, or abdominal discomfort. Taking the medication with food or adjusting the dosage may help reduce these symptoms.
  • Hepatotoxicity: Rifampicin can lead to liver toxicity in some individuals, resulting in elevated liver enzymes and jaundice. Liver function should be monitored during treatment.
  • Flu-Like Symptoms: Some patients may experience flu-like symptoms, including fever, chills, and muscle aches, particularly during the initial weeks of treatment.
  • Skin Discoloration: Rifampicin can cause harmless discoloration of bodily fluids, such as urine, sweat, saliva, and tears, turning them an orange-red color. This is not harmful but can be surprising.
  • Drug Interactions: Rifampicin is known to interact with various medications, including oral contraceptives and anticoagulants, potentially reducing their effectiveness. Patients should inform their healthcare provider of all medications they are taking.
  • Allergic Reactions: While rare, allergic reactions to Rifampicin can occur, presenting as rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if such symptoms occur.
  • Peripheral Neuropathy: Prolonged use of Rifampicin, especially in high doses, may lead to peripheral neuropathy, causing tingling, numbness, or weakness in the extremities.
  • Hemolysis: Rifampicin can lead to the destruction of red blood cells (hemolysis), which can be problematic for individuals with certain blood disorders.

Frequently Asked Questions about Rifampicin Capsules USP:

  • What is Rifampicin Capsules USP?

Rifampicin Capsules USP are a medication used to treat various bacterial infections. They contain the active ingredient rifampicin, which is an antibiotic.

  • What conditions are Rifampicin Capsules USP prescribed for?

Rifampicin is commonly prescribed to treat tuberculosis (TB) and certain other bacterial infections, including leprosy and infections caused by Mycobacterium species.

  • How do I take Rifampicin Capsules USP?

The dosage and duration of treatment with Rifampicin Capsules USP will depend on your specific condition and your doctor’s instructions. Typically, it is taken orally with or without food. It’s important to follow your healthcare provider’s recommendations closely.

  • What are the common side effects of Rifampicin Capsules USP?

Common side effects may include nausea, vomiting, diarrhea, stomach cramps, and changes in urine color (usually orange-red). Rifampicin can also cause more serious side effects, so it’s important to report any unusual symptoms to your doctor.

  • Can I drink alcohol while taking Rifampicin Capsules USP?

It’s generally not recommended to consume alcohol while taking Rifampicin, as it can increase the risk of liver problems and may reduce the effectiveness of the medication. Be sure to discuss this with your healthcare provider.

  • Are there any drug interactions with Rifampicin Capsules USP?

Rifampicin can interact with several medications, including birth control pills, anticoagulants, and certain antiretroviral drugs. Inform your doctor about all the medications and supplements you are taking to avoid potential interactions.

  • Can I stop taking Rifampicin Capsules USP once my symptoms improve?

No, it’s crucial to complete the full course of Rifampicin Capsules USP as prescribed by your doctor, even if your symptoms improve before the medication is finished. Stopping prematurely can lead to the development of drug-resistant bacteria.

  • How should I store Rifampicin Capsules USP?

Store Rifampicin Capsules USP at room temperature, away from direct sunlight and moisture. Keep them out of reach of children.

  • Is Rifampicin Capsules USP safe during pregnancy and breastfeeding?

It’s essential to consult your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as they will assess the risks and benefits of using Rifampicin in your specific situation.

  • What should I do if I miss a dose of Rifampicin Capsules USP?

If you miss a dose, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

As Rifampicin Capsules USP Exporters; We can cater to export business queries from the following geographies. We are exporting our Rifampicin Capsules USP product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Rifampicin Capsules USP Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Rifampicin Capsules USP, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274

GENERIC NAME OF THE MEDICINAL PRODUCT:

QUALITATIVE AND QUANTITATIVE COMPOSITION:

THERAPEUTIC INDICATIONS:

Rifampin is used together with other medicines to treat tuberculosis (TB) in many different parts of the body. It is also used by patients who have a meningitis bacteria in their nose or throat who do not show symptoms of the infection to prevent the spread of the bacteria to other patients.

CAUTION & WARNING:

CAUTION: SWALLOW WHOLE DO NOT CHEW OR CRUSH
Read enclosed leaflet before use.
KEEP MEDICINE OUT OF REACH OF CHILDREN.
WARNING: To be sold by retail on the prescription of a Registered Medical Practitioner only.

STORAGE & DOSAGE:

Storage: Store at 20° to 25°C (68° to 77°F)
Dosage: As directed by the Physician.
Attach dispensing label as per end country.