Pyrimethamine Tablets USP 25mg Technical Specification:

Product Name:Pyrimethamine Tablets USP 25mg
Brand Name:Generic
Strength:25mg
Dosage Form:Tablets (Uncoated)
Route of Administration:Via Oral Route
Packing:10s, 30s, 100s, 500s
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Antiparasitic
Indication: Pyrimethamine belongs to a class of drugs known as antiparasitics. It works by killing parasites.
Storage:Store at 15°C – 25°C in dry place.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Pyrimethamine Tablets USP 25mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Pyrimethamine Tablets USP 25mg
    Each uncoated tablet contains:
    Pyrimethamine USP…………………25mg
    Excipients…………………………q.s.
    Colours: Lake tartrazine

THERAPEUTIC INDICATIONS:

Pyrimethamine is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection. Pyrimethamine belongs to a class of drugs known as antiparasitics. It works by killing parasites.

CAUTION & WARNING:

CAUTION: SWALLOW WHOLE DO NOT CHEW OR CRUSH.
Read enclosed leaflet before use.
Keep medicine out of reach of children.
WARNING: To be sold by retail on the prescription of a Registered Medical Practitioner only.

STORAGE & DOSAGE:

Storage:  Store at 15°C – 25°C in dry place.
Dispense in tight and light resistant container as defined in the USP.
Dosage: As directed by the Physician.

Why Taj pharmaceuticals?

At Taj Pharmaceuticals, we are dedicated to providing high-quality medications to combat malaria and parasitic infections. Pyrimethamine Tablets play a crucial role in global healthcare, particularly in regions where these infections are prevalent. Our commitment to pharmaceutical excellence is reflected in our rigorous quality control processes, ensuring that you receive medication that meets the highest international standards. Malaria, caused by the Plasmodium parasite, is a major global health concern, especially in tropical and subtropical regions. Pyrimethamine is a vital component of malaria treatment and prevention strategies. It works by inhibiting the growth and reproduction of the parasite within the red blood cells, ultimately reducing the severity of the disease. In addition to its use in malaria, Pyrimethamine is also employed in the treatment of certain parasitic infections, such as toxoplasmosis. This versatility makes it an essential medication in the fight against various infectious diseases. Our commitment to patient well-being extends beyond the manufacturing process. We understand the critical role that Pyrimethamine Tablets play in preventing and treating these diseases, and we take our responsibility seriously. By choosing Taj Pharmaceuticals, you choose a partner that prioritizes your health and safety, ensuring that you receive pharmaceutical products of the highest quality. With a global presence and a track record of excellence, Taj Pharmaceuticals is a trusted source for Pyrimethamine Tablets. Join us in the fight against malaria and parasitic infections, and experience the difference that pharmaceutical quality and commitment to patient care can make in improving lives worldwide. Trust Taj Pharmaceuticals for your medication needs and be part of our mission to create a healthier, disease-free world.

What is Pyrimethamine Tablets and its uses:

Pyrimethamine Tablets are a medication primarily used for the treatment and prevention of certain parasitic infections, as well as the prevention and treatment of malaria. Pyrimethamine is the active ingredient in these tablets, and it works by inhibiting the growth and reproduction of parasites.

Here are the main uses of Pyrimethamine Tablets:

  • Malaria Treatment: Pyrimethamine is one of the essential drugs used in combination therapies to treat malaria, particularly infections caused by the Plasmodium falciparum parasite. It is often used in combination with other antimalarial drugs, such as sulfadoxine, to increase effectiveness and reduce the risk of drug resistance. Pyrimethamine works by targeting the asexual blood stages of the parasite’s life cycle.
  • Malaria Prophylaxis: In regions where malaria is endemic or for travelers visiting malaria-prone areas, Pyrimethamine Tablets may be prescribed as a preventive measure to reduce the risk of contracting malaria. It is often used in combination with other antimalarial medications.
  • Toxoplasmosis Treatment: Pyrimethamine is also used to treat toxoplasmosis, an infection caused by the Toxoplasma gondii parasite. This infection can affect various organs, including the brain and eyes. Pyrimethamine, often combined with sulfadiazine, is effective in reducing the severity of toxoplasmosis and preventing its complications.
  • Preventing Congenital Toxoplasmosis: Pregnant women who are at risk of toxoplasmosis or have been exposed to the Toxoplasma parasite may be prescribed Pyrimethamine as a preventive measure to reduce the risk of transmitting the infection to the fetus.
  • Treatment of Other Parasitic Infections: In some cases, Pyrimethamine may be used to treat other parasitic infections, although its use for these purposes is less common.

It’s important to note that Pyrimethamine Tablets are typically prescribed and administered under the supervision of a healthcare provider, as the dosage and duration of treatment can vary depending on the specific infection being treated and the patient’s medical history. Additionally, this medication should be taken as directed to ensure its effectiveness and reduce the risk of developing resistance in parasites.

How does Pyrimethamine Tablets Work:

Pyrimethamine Tablets work by targeting the metabolism and reproduction of certain parasites, including the malaria-causing Plasmodium species and the Toxoplasma gondii parasite. Pyrimethamine is a medication that belongs to a class of drugs known as antifolate agents. Here’s how Pyrimethamine works:

  • Inhibition of Folate Metabolism: Parasites, including malaria parasites and Toxoplasma gondii, rely on folate (a B-vitamin) for their growth and replication. Folate is essential for the synthesis of DNA and RNA, which are critical for cell division and reproduction.
  • Blocking Dihydrofolate Reductase: Pyrimethamine primarily inhibits an enzyme called dihydrofolate reductase (DHFR), which is essential for the synthesis of tetrahydrofolate (THF). THF is a crucial cofactor in the synthesis of DNA and RNA.
  • Deprivation of Nucleotide Precursors: By inhibiting DHFR, Pyrimethamine interferes with the production of THF. As a result, the parasites are unable to synthesize nucleotides (the building blocks of DNA and RNA) and cannot replicate their genetic material effectively.
  • Impaired Reproduction: When parasites cannot replicate their DNA and RNA, their ability to reproduce is severely compromised. This leads to a decrease in the number of parasites in the body, ultimately reducing the severity of the infection.
  • Malaria Parasite Target: Pyrimethamine is particularly effective against Plasmodium falciparum, one of the species responsible for severe cases of malaria. This drug is often used in combination with other antimalarial medications to enhance its effectiveness and reduce the risk of resistance.
  • Toxoplasma gondii Inhibition: Pyrimethamine is also effective against Toxoplasma gondii, the parasite responsible for toxoplasmosis. It disrupts the replication and growth of the parasite within host cells, reducing the impact of the infection.

It’s important to note that Pyrimethamine is typically used in combination with other medications, such as sulfadoxine or sulfadiazine, to create synergistic effects in the treatment of malaria and toxoplasmosis. Combining different antifolate agents helps reduce the likelihood of resistance developing in the parasites. The precise dosage and duration of Pyrimethamine treatment depend on the specific infection being treated, the patient’s age, weight, and medical history, and the drug resistance patterns in the region. Pyrimethamine should only be taken under the guidance and prescription of a healthcare provider to ensure its safe and effective use.

Benefits of Pyrimethamine Tablets:

  • Treatment of Malaria: Pyrimethamine is a valuable component of antimalarial combination therapies. It helps to effectively treat malaria, especially infections caused by Plasmodium falciparum, which can be severe and life-threatening.
  • Malaria Prevention: When used as part of prophylactic treatment, Pyrimethamine can reduce the risk of contracting malaria for travelers and individuals living in malaria-endemic regions.
  • Toxoplasmosis Treatment: Pyrimethamine is highly effective in the treatment of toxoplasmosis, a parasitic infection that can affect multiple organs, including the brain. It helps reduce the severity of the infection and prevent complications.
  • Prevention of Congenital Toxoplasmosis: Pyrimethamine may be prescribed to pregnant women at risk of toxoplasmosis to prevent the transmission of the parasite to the fetus, reducing the risk of congenital toxoplasmosis.

Side Effects of Pyrimethamine Tablets:

  • Gastrointestinal Upset: Common side effects may include nausea, vomiting, and diarrhea. Taking Pyrimethamine with food can help alleviate these symptoms.
  • Mouth Ulcers: Some individuals may experience mouth ulcers or sores while taking Pyrimethamine.
  • Skin Reactions: Skin rashes and itching are possible side effects, although they are less common.
  • Blood Disorders: Pyrimethamine can affect blood cell counts, leading to anemia (reduced red blood cell count) or leukopenia (reduced white blood cell count). Regular blood tests may be necessary to monitor for these effects.
  • Folate Deficiency: Pyrimethamine’s mechanism of action involves blocking folate metabolism, which can lead to a deficiency of folate (vitamin B9) in the body. Healthcare providers may recommend folate supplementation to counteract this effect.
  • Allergic Reactions: In rare cases, Pyrimethamine can cause severe allergic reactions, including swelling of the face, lips, tongue, or throat, difficulty breathing, and hives. Seek immediate medical attention if you experience these symptoms.
  • Neurological Effects: High doses of Pyrimethamine, especially in long-term use, may lead to neurological side effects, including headaches, dizziness, and confusion.
  • Liver and Kidney Function: Pyrimethamine can affect liver and kidney function, and regular monitoring may be necessary in individuals with pre-existing liver or kidney conditions.
  • Drug Interactions: Pyrimethamine may interact with other medications, potentially reducing their effectiveness or increasing the risk of side effects. It’s important to inform your healthcare provider about all medications you are taking.
  • Folate Antagonism in Pregnancy: Pyrimethamine should be used with caution in pregnant women, as it can interfere with folate metabolism, which is important for fetal development. The benefits and risks should be carefully assessed by a healthcare provider.

It’s crucial to use Pyrimethamine Tablets as prescribed by a healthcare provider and to report any unusual or severe side effects promptly. This medication is typically administered under medical supervision, especially for the treatment of malaria and toxoplasmosis, to ensure its safe and effective use.

Frequently Asked Questions About Pyrimethamine Tablets:

Certainly, here are some frequently asked questions (FAQs) about Pyrimethamine Tablets:

  1. What is Pyrimethamine used for?

Pyrimethamine is primarily used for the treatment and prevention of malaria, as well as for the treatment of parasitic infections like toxoplasmosis.

  1. How does Pyrimethamine work against malaria?

Pyrimethamine works by inhibiting the growth and reproduction of the malaria parasite, particularly Plasmodium falciparum. It disrupts the parasite’s ability to synthesize DNA and RNA, which are essential for its survival.

  1. Is Pyrimethamine used alone to treat malaria?

Pyrimethamine is typically used in combination with other antimalarial drugs, such as sulfadoxine, to enhance its effectiveness and reduce the risk of drug resistance.

  1. Can Pyrimethamine be used for malaria prevention?

Yes, Pyrimethamine can be used as a preventive measure for travelers visiting malaria-endemic regions. It is often prescribed in combination with other antimalarial medications.

  1. What is the role of Pyrimethamine in toxoplasmosis treatment?

Pyrimethamine is a key component in the treatment of toxoplasmosis, especially when combined with sulfadiazine. It helps reduce the severity of the infection and prevents complications.

  1. Are there any common side effects of Pyrimethamine Tablets?

Common side effects may include gastrointestinal symptoms like nausea, vomiting, and diarrhea. Some individuals may also experience mouth ulcers, skin rashes, or itching.

  1. Is Pyrimethamine safe during pregnancy?

Pyrimethamine should be used with caution during pregnancy, especially in the first trimester, due to its potential to interfere with fetal folate metabolism. The benefits and risks should be assessed by a healthcare provider.

  1. Can Pyrimethamine cause allergies or severe reactions?

While rare, Pyrimethamine can cause severe allergic reactions, including swelling of the face and difficulty breathing. Seek immediate medical attention if you experience such symptoms.

  1. Is regular monitoring necessary while taking Pyrimethamine?

Yes, regular blood tests may be required to monitor blood cell counts and ensure that Pyrimethamine is not causing anemia or other blood related issues.

  1. Can Pyrimethamine interact with other medications?

Pyrimethamine may interact with other drugs, potentially reducing their effectiveness or increasing the risk of side effects. Inform your healthcare provider about all medications you are taking.

  1. Is Pyrimethamine suitable for children?

Pyrimethamine can be prescribed to children for the treatment and prevention of malaria and certain parasitic infections. The dosage is adjusted based on the child’s age and weight.

Always follow the specific instructions provided by your healthcare provider when taking Pyrimethamine Tablets, and discuss any concerns or questions you may have about its use, potential side effects, or interactions with other medications.

As Pyrimethamine Tablets Exporters; We can cater to export business queries from the following geographies. We are exporting our Pyrimethamine Tablets product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Pyrimethamine Tablets Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Pyrimethamine Tablets, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593

GENERIC NAME OF THE MEDICINAL PRODUCT:

A) Pyrimethamine Tablets USP 25mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

A) Pyrimethamine Tablets USP 25mg
Each uncoated tablet contains:
Pyrimethamine USP…………………25mg
Excipients…………………………q.s.
Colours: Lake tartrazine


THERAPEUTIC INDICATIONS:

Pyrimethamine is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection. Pyrimethamine belongs to a class of drugs known as antiparasitics. It works by killing parasites.

CAUTION & WARNING:

CAUTION:
SWALLOW WHOLE DO NOT CHEW OR CRUSH.
Read enclosed leaflet before use.
KEEP MEDICINE OUT OF REACH OF CHILDREN.
WARNING: TO BE SOLD BY RETAIL ON THE PRESCRIPTION OF A REGISTERED MEDICAL PRACTITIONER ONLY.

STORAGE & DOSAGE:

Storage: Store at 15°C - 25°C in dry place.
Dispense in tight and light resistant container as defined in the USP.
Dosage: As directed by the Physician.