Primaquine Phosphate Tablet IP 15 mg Technical Specification:

Product Name:                    Primaquine Phosphate Tablet IP 15mg
Brand Name:Generics
Strength:(7.5mg), (15mg)
Dosage Form:Tablet (Film-coated)
Route of Administration:Via oral Route
Packing:10s, 30s, 100s
Pack Insert/Leaflet:PIL (Patient Information Leaflet)
Regulatory Documents:COA, MOA, Stability Studies, GMP
Therapeutic use:Antimalarial
Indication: Primaquine phosphate is an 8-aminoquinoline compound which eliminates tissue (exoerythrocytic) infection. Thereby, it prevents the development of the blood (erythrocytic) forms of the parasite which are responsible for relapses in vivax malaria.
Storage:Protect form moisture at a temperature not exceeding 30˚C.Do not freeze. Keep the container tightly closed in order to protect from moisture.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Primaquine Phosphate Tablet IP 15mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Primaquine Phosphate Tablet IP 15mg
    Each Film-coated tablet contains:
    Primaquine Phosphate I.P
    Eq. to Primaquine.…………………………….15mg
    Excipients…………………………………. q.s.
    Colours: Ferric Oxide Red

THERAPEUTIC INDICATIONS:

Primaquine phosphate is an 8-aminoquinoline compound which eliminates tissue (exoerythrocytic) infection. Thereby, it prevents the development of the blood (erythrocytic) forms of the parasite which are responsible for relapses in vivax malaria.

CAUTION & WARNING:

CAUTION:  Read enclosed leaflet before use.
Keep medicine out of reach of children.
SWALLOW WHOLE DO NOT CHEW OR CRUSH

SCHEDULE “H” Prescription Drug -Warning: Not to be sold by retail without the prescription of a Registered Medical Prescriber.

STORAGE & DOSAGE:

Storage:  Protect form moisture at a temperature not exceeding 30˚C.Do not freeze. Keep the container tightly closed in order to protect from moisture.

Dosage:  As directed by the Physician.

Why Taj Pharmaceuticals?

When it comes to Primaquine Phosphate Tablets IP, Taj Pharma stands out as a leader in the pharmaceutical industry. With a rich history of delivering cutting-edge healthcare solutions, we are dedicated to making a positive impact on global health. Our Primaquine Phosphate Tablets are meticulously formulated to combat malaria effectively, ensuring the well-being of patients worldwide. At Taj Pharma, our commitment to quality extends beyond the product itself. We prioritize rigorous testing, stringent quality control measures, and compliance with international pharmaceutical standards, giving you confidence in the safety and efficacy of our medications. Moreover, we offer accessibility and affordability, making essential healthcare accessible to all.  Choose Taj Pharma for Primaquine Phosphate Tablets IP and join countless healthcare professionals and patients who rely on our expertise and dedication to improving lives. Experience the difference with Taj Pharma, where your health is our top priority.

What is Primaquine Phosphate Tablets IP and Its Use?

Primaquine Phosphate Tablets IP is a medication used primarily in the treatment and prevention of malaria, a serious and sometimes life-threatening mosquito-borne infectious disease. This medication contains the active ingredient primaquine phosphate, which is an anti-malarial drug.

Here’s a breakdown of its primary uses:

  • Malaria Treatment: Primaquine is particularly effective against certain forms of malaria parasites, including the Plasmodium vivax and Plasmodium ovale species, which can form dormant liver stages (hypnozoites). Primaquine helps eliminate these dormant parasites from the liver, preventing relapses of malaria infection. It is often used in combination with other anti-malarial drugs to treat both the acute infection in the blood and the dormant liver stages.
  • Malaria Prophylaxis: In some cases, Primaquine Phosphate Tablets may also be prescribed to individuals traveling to areas where malaria is prevalent as a preventive measure. It can help reduce the risk of contracting malaria when taken before, during, and after exposure to the disease, depending on the specific regimen recommended by healthcare professionals.

Primaquine should be used under the guidance and supervision of a healthcare provider, as its dosage and administration can vary based on factors such as the type of malaria parasite, the patient’s age, weight, and medical history. Primaquine may not be suitable for everyone, and it may have certain side effects or interactions with other medications. It’s crucial to consult with a healthcare professional before using Primaquine Phosphate Tablets to ensure it is the right treatment option for your specific situation and to receive proper instructions on its usage.

How does Primaquine Phosphate Tablets IP Work?

Primaquine Phosphate Tablets IP work by targeting and eliminating specific stages of the malaria parasite’s life cycle, primarily in the liver. Here’s a simplified overview of how Primaquine works:

  • Attack on Liver Stages: Primaquine is particularly effective against malaria parasites like Plasmodium vivax and Plasmodium ovale that can form dormant liver stages, known as hypnozoites. After being bitten by an infected mosquito, these parasites enter the bloodstream and eventually make their way to the liver, where they remain dormant.
  • Activation of Hypnozoites: Primaquine is unique in that it can activate and kill these dormant liver-stage parasites. When you take Primaquine tablets, the drug is metabolized in the liver, and its active form disrupts the membranes of the hypnozoites, essentially killing them.
  • Prevention of Relapses: By eliminating the dormant liver-stage parasites, Primaquine helps prevent relapses of malaria. Without this drug, these dormant parasites can reactivate weeks, months, or even years after the initial infection, causing recurrent episodes of the disease.
  • Combination Therapy: Primaquine is often used in combination with other anti-malarial drugs, such as chloroquine or artemisinin-based combination therapies, to treat both the acute infection in the bloodstream (blood-stage parasites) and the dormant liver stages. This combination therapy ensures comprehensive treatment and reduces the risk of drug resistance.

Primaquine should be taken as prescribed by a healthcare provider, as the dosage and duration of treatment can vary based on factors such as the type of malaria parasite and the individual patient’s medical history. Additionally, while Primaquine is effective against certain malaria species, it may not be effective against all types of malaria, so its use should be tailored to the specific malaria endemic in a region.

Benefits and Side Effects of Primaquine Phosphate Tablets IP?

Primaquine Phosphate Tablets IP offer significant benefits in the treatment and prevention of malaria, particularly against certain types of the disease. However, like any medication, they can also have potential side effects. Here’s an overview of the benefits and potential side effects:

Benefits:

  • Effective Against Relapsing Malaria: Primaquine is particularly effective against malaria caused by Plasmodium vivax and Plasmodium ovale parasites, which can form dormant liver stages (hypnozoites). It helps prevent relapses of the disease by eliminating these dormant parasites.
  • Preventive Measure: Primaquine can be used as a prophylactic (preventive) treatment for individuals traveling to regions where malaria is prevalent. It can reduce the risk of contracting malaria when taken before, during, and after exposure to the disease.
  • Combination Therapy: It is often used in combination with other anti-malarial drugs, such as chloroquine or artemisinin-based combination therapies, to provide comprehensive treatment and reduce the risk of drug resistance.
  • Wide Availability: Primaquine is a well-established medication and is available in many parts of the world, making it accessible for the treatment and prevention of malaria.

Side Effects:

  • Gastrointestinal Disturbances: Common side effects of Primaquine may include nausea, vomiting, abdominal cramps, and diarrhea. Taking the medication with food can help reduce these symptoms.
  • Hemolysis: Primaquine can cause a condition called hemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. This condition involves the destruction of red blood cells, leading to symptoms like anemia and jaundice. G6PD deficiency is more common in certain populations, so individuals are usually screened for this condition before starting Primaquine.
  • Hypersensitivity Reactions: Rarely, some individuals may experience allergic reactions to Primaquine, which can manifest as skin rashes, itching, or swelling of the face and throat. If severe allergic reactions occur, immediate medical attention is necessary.
  • Other Side Effects: Primaquine may also lead to headaches, dizziness, and changes in blood pressure. These side effects are less common but should be reported to a healthcare provider if they occur.

Frequently asked questions (FAQs) about Primaquine Phosphate Tablets IP:

  1. What is Primaquine Phosphate Tablets used for?

Primaquine Phosphate Tablets are primarily used for the treatment and prevention of malaria, especially against certain malaria parasites like Plasmodium vivax and Plasmodium ovale that form dormant liver stages.

  1. How does Primaquine work against malaria?

Primaquine works by activating and eliminating dormant liverstage parasites, preventing relapses of malaria. It also helps in combination therapy to treat acute bloodstage malaria.

  1. Is Primaquine effective against all types of malaria?

No, Primaquine is most effective against specific malaria parasites that form dormant liver stages, such as Plasmodium vivax and Plasmodium ovale. It may not be effective against all types of malaria.

  1. Can Primaquine be used for malaria prevention when traveling to endemic areas?

Yes, Primaquine can be used as a prophylactic (preventive) measure for individuals traveling to regions where malaria is prevalent. It reduces the risk of contracting malaria when taken as prescribed.

  1. Are there any side effects associated with Primaquine?

Yes, common side effects may include gastrointestinal disturbances like nausea, vomiting, and diarrhea. It can also cause hemolysis in individuals with glucose6phosphate dehydrogenase (G6PD) deficiency, leading to anemia and jaundice.

  1. Is Primaquine safe for everyone?

Primaquine may not be safe for individuals with G6PD deficiency, certain allergies, or other specific medical conditions. It should be used under the guidance of a healthcare provider who can assess its suitability for each individual.

  1. How should Primaquine Phosphate Tablets be taken?

Primaquine should be taken exactly as prescribed by a healthcare provider, typically with food to reduce gastrointestinal side effects. The dosage and duration of treatment will vary based on the specific malaria parasite and the individual’s medical history.

  1. Is Primaquine readily available?

Primaquine is a wellestablished medication and is available in many regions where malaria is a concern. However, its availability may vary, so it’s important to check with local healthcare providers or pharmacies

  1. Can Primaquine be taken during pregnancy or while breastfeeding?

The use of Primaquine during pregnancy or breastfeeding should be carefully considered and prescribed by a healthcare provider, taking into account the potential risks and benefits.

  1. What should I do if I experience unusual or severe side effects while taking Primaquine?

If you experience any concerning side effects, especially severe allergic reactions, seek immediate medical attention and inform your healthcare provider about your symptoms.

As Primaquine Phosphate Tablets IP Exporters; We can cater to export business queries from the following geographies. We are exporting our Primaquine Phosphate Tablets IP product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Primaquine Phosphate Tablets IP Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Primaquine Phosphate Tablets IP, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274

GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Primaquine Phosphate Tablet IP 7.5mg
B. Primaquine Phosphate Tablet IP 15mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

A. Primaquine Phosphate Tablet IP 7.5mg
Each Film-coated tablet contains:
Primaquine Phosphate I.P
Eq. to Primaquine.…………………………….7.5mg
Excipients…………………………………. q.s.
Colours: Titanium Dioxide IP

B. Primaquine Phosphate Tablet IP 15mg
Each Film-coated tablet contains:
Primaquine Phosphate I.P
Eq. to Primaquine.…………………………….15mg
Excipients…………………………………. q.s.
Colours: Ferric Oxide Red


THERAPEUTIC INDICATIONS:

Primaquine phosphate is an 8-aminoquinoline compound which eliminates tissue (exoerythrocytic) infection. Thereby, it prevents the development of the blood (erythrocytic) forms of the parasite which are responsible for relapses in vivax malaria.

CAUTION & WARNING:

CAUTION:
Read enclosed leaflet before use.
KEEP MEDICINE OUT OF REACH OF CHILDREN.
SWALLOW WHOLE DO NOT CHEW OR CRUSH
SCHEDULE “H” Prescription Drug -Warning: Not to be sold by retail without the prescription of a Registered Medical Prescriber.

STORAGE & DOSAGE:

Storage: Protect form moisture at a temperature not exceeding 30˚C.Do not freeze. Keep the container tightly closed in order to protect from moisture.
Dosage: As directed by the Physician.