Perindopril Arginine & Amlodipine Besilate Tablets 5mg+5mg Technical Specification:

Product Name:Perindopril Arginine & Amlodipine Besilate Tablets (5mg+5mg)
Brand Name:COVETAJ
Strength:(5mg+5mg), (5mg+10mg), (10mg+5mg), (10mg+10mg), (3.5mg+2.5mg), (7mg+5mg), (14mg+10mg)
Dosage Form:Film-coated tablets
Packing:30s Blisters
20 Tab Bottle, 30 Tab Bottle, 90 Tab Bottle
Route of Administration:For Oral Use Only
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Hypertensive/ Anti-CAD (coronary artery disease)
Indication: Perindopril Arginine & Amlodipine Besilate Tablets used for lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Storage:Store protected from moisture at a temperature not exceeding 25°C.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Perindopril Arginine & Amlodipine Besilate Tablets (5mg+5mg)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Perindopril Arginine & Amlodipine Besilate Tablets (5mg+5mg)
    Composition:
    Each film-coated tablet contains:
    Perindopril 3.395mg Corresponding to
    Perindopril Arginine …………………….….5mg
    Amlodipine Besilate ……………………6.935mg
    Equivalent to Amlodipine……………5mg
    Excipients…………………………………. q.s.
    Colours: Titanium Dioxide USP

THERAPEUTIC INDICATIONS:

Perindopril Arginine & Amlodipine Besilate Tablets used for lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Perindopril belongs to a class of drug known as ACE inhibitors and amlodipine belongs to a class of drug known as calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

DIRECTIONS:

Take this medicine at the same time each day. Taking it at the same time each day will have the best effect and will also help you remember when to take it.
This medicine should be taken in the morning before meal.

CAUTION & WARNING:

CAUTION: Do not throw away consumer package insert.

Swallow whole do not chew or crush.

WARNING: Do not skip/discontinue the dose for effective treatment.

Do not stop taking your medicine or change your dosage without consulting your doctor.

This medicine should not be used in children.

Keep out of the reach and sight of children.

STORAGE & DOSAGE:

Storage:  Store protected from moisture at a temperature not exceeding 25°C.

Dosage: As directed by the Physician.

Your doctor will tell you how much of this medicine you should take.
The usual dose is 1 tablet once daily.

Note: Swallow your tablet with a glass of water.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals stands as a reputable and reliable source for Perindopril Arginine & Amlodipine Besilate Tablets, a trusted combination medication for the effective management of hypertension and associated cardiovascular conditions. Our unwavering dedication to pharmaceutical excellence, quality, and patient well-being has solidified our position as a trusted partner in the journey to optimal cardiovascular health. With a rich history spanning decades in the pharmaceutical industry, Taj Pharmaceuticals is committed to ensuring that each tablet of Perindopril Arginine & Amlodipine Besilate adheres to the highest global standards of quality and safety. We prioritize accessibility, striving to ensure that individuals seeking effective blood pressure control have access to top-quality pharmaceuticals. Our state-of-the-art manufacturing facilities are equipped with the latest technology and stringent quality control measures to guarantee the efficacy and safety of every dose. Whether you are striving for improved blood pressure management or enhanced cardiovascular well-being, healthcare professionals trust Taj Pharmaceuticals for reliable and effective medications. Select Taj Pharmaceuticals for Perindopril Arginine & Amlodipine Besilate Tablets and experience pharmaceutical excellence that places your health and well-being at the forefront. We are your steadfast partner on the path to better cardiovascular health, providing the quality, reliability, and accessibility you deserve for a healthier life. Trust Taj Pharmaceuticals for your cardiovascular health needs.

What is Perindopril Arginine & Amlodipine Besilate Tablets and its uses:

Perindopril Arginine & Amlodipine Besilate Tablets are a combination medication used in the treatment of hypertension (high blood pressure). This medication combines two active ingredients, perindopril arginine and amlodipine besilate, which work together to help lower blood pressure and manage hypertension effectively.

  • Perindopril Arginine: Perindopril is an angiotensin converting enzyme (ACE) inhibitor. It works by relaxing blood vessels, which allows blood to flow more easily. This effect reduces the resistance in the arteries and lowers blood pressure.
  • Amlodipine Besilate: Amlodipine belongs to a class of drugs known as calcium channel blockers. It relaxes and widens blood vessels by blocking the influx of calcium into the muscle cells of the blood vessel walls. This action also helps lower blood pressure.
Uses: Perindopril Arginine & Amlodipine Besilate Tablets are used for several important medical purposes, primarily in the treatment of hypertension (high blood pressure). Here are the primary uses of this combination medication:
  • Hypertension (High Blood Pressure): The primary and most common use of Perindopril Arginine & Amlodipine Besilate Tablets is to lower elevated blood pressure in individuals diagnosed with hypertension. The combination of perindopril (an ACE inhibitor) and amlodipine besilate (a calcium channel blocker) helps relax blood vessels, reduce resistance in the arteries, and improve blood flow. By effectively lowering blood pressure, this medication helps reduce the risk of cardiovascular complications associated with hypertension, such as heart attacks, strokes, and heart failure.
  • Cardiovascular Risk Reduction: Lowering blood pressure with this medication also helps reduce the overall cardiovascular risk in patients with hypertension. It can help protect the heart, blood vessels, and other vital organs from the damage caused by chronic high blood pressure.
  • Combination Therapy: Perindopril and amlodipine are often combined in a single tablet because they work through different mechanisms to lower blood pressure. This combination therapy can be particularly beneficial for patients who require both an ACE inhibitor and a calcium channel blocker to achieve optimal blood pressure control.
  • Coronary Artery Disease: In some cases, this medication may be prescribed to individuals with coronary artery disease (CAD) or angina (chest pain). Amlodipine, as a calcium channel blocker, can help improve blood flow to the heart muscle, reducing the frequency and severity of angina attacks.
  • Management of Hypertensive Patients: Perindopril Arginine & Amlodipine Besilate Tablets are used for individuals with moderate to severe hypertension or for those who do not achieve adequate blood pressure control with a single antihypertensive medication. The combination can offer more effective blood pressure management.

It’s important to note that the use of this medication should be prescribed and supervised by a healthcare provider. The dosage and treatment plan will vary based on the individual’s specific medical condition and blood pressure goals. Patients should follow their healthcare provider’s instructions, attend regular check-ups, and monitor their blood pressure to ensure optimal management of hypertension and overall cardiovascular health.

How does Perindopril Arginine & Amlodipine Besilate Tablets work?

Perindopril Arginine & Amlodipine Besilate Tablets work through a combination of two active ingredients, perindopril arginine and amlodipine besilate, to effectively lower blood pressure and manage hypertension. These two medications have different mechanisms of action that complement each other:

  • Perindopril (ACE Inhibitor): Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. ACE inhibitors block the action of the enzyme ACE, which plays a role in the renin-angiotensin-aldosterone system (RAAS). The RAAS system regulates blood pressure and fluid balance in the body. By inhibiting ACE, perindopril reduces the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor (it narrows blood vessels), and it also stimulates the release of aldosterone, which leads to sodium and water retention. The net effect of perindopril is vasodilation (relaxation and widening of blood vessels), which reduces resistance in the arteries. This results in lower blood pressure as the heart pumps blood against less resistance. Additionally, perindopril helps decrease sodium and water retention, further lowering blood volume and pressure.
  • Amlodipine Besilate (Calcium Channel Blocker): Amlodipine besilate is a calcium channel blocker. It acts by inhibiting the influx of calcium ions into the muscle cells of the blood vessel walls. Calcium plays a crucial role in muscle contraction, including the contraction of smooth muscle in blood vessels. By blocking calcium channels, amlodipine relaxes the smooth muscle cells in blood vessel walls, causing them to dilate (widen). The dilation of blood vessels reduces peripheral vascular resistance, allowing blood to flow more easily. This results in lower blood pressure and improved blood flow to various tissues and organs.
  • Combined Effect: The combination of perindopril and amlodipine in a single tablet leverages their complementary mechanisms of action. While perindopril primarily works by reducing peripheral resistance, amlodipine directly relaxes blood vessels. This dual action helps achieve effective blood pressure reduction in individuals with hypertension.

Overall, Perindopril Arginine & Amlodipine Besilate Tablets provide a synergistic effect, effectively lowering blood pressure and reducing the risk of complications associated with hypertension, such as cardiovascular events and organ damage. These tablets are prescribed by healthcare providers based on the individual patient’s condition and blood pressure management needs.

Benefits of Perindopril Arginine & Amlodipine Besilate Tablets:

  • Effective Blood Pressure Control: These tablets are highly effective in lowering and controlling high blood pressure (hypertension). They combine two different classes of antihypertensive medications, providing a more comprehensive approach to blood pressure management.
  • Cardiovascular Protection: Lowering blood pressure with this medication can help protect the heart and blood vessels from the damage caused by chronic hypertension. It reduces the risk of cardiovascular events such as heart attacks and strokes.
  • Combination Therapy: The combination of perindopril (ACE inhibitor) and amlodipine (calcium channel blocker) offers a synergistic effect. It addresses blood pressure regulation through different mechanisms, making it suitable for patients who require both types of medications.
  • Improved Blood Flow: Amlodipine, as a calcium channel blocker, helps improve blood flow to various organs, including the heart. This can be beneficial for individuals with coronary artery disease and angina, as it reduces the frequency and severity of chest pain.
  • Reduced Risk of Hypertensive Complications: By effectively lowering blood pressure, these tablets help reduce the risk of complications associated with hypertension, such as kidney damage, vision problems, and cognitive impairment.

Side Effects of Perindopril Arginine & Amlodipine Besilate Tablets:

  • Dizziness: Some individuals may experience dizziness, especially when standing up quickly. This can be more common when starting the medication or with dosage adjustments.
  • Swelling (Edema): Amlodipine can cause peripheral edema, which is the swelling of the ankles, feet, or legs. This side effect is usually mild and may improve with time.
  • Cough: ACE inhibitors like perindopril can sometimes cause a persistent dry cough in some patients. If this occurs, it should be reported to a healthcare provider.
  • Headache: Headaches can occur as a side effect, particularly during the initial stages of treatment.
  • Flushing or Warmth: Some individuals may experience a sensation of warmth or flushing of the skin.
  • Gastrointestinal Symptoms: Gastrointestinal side effects such as nausea, abdominal pain, or diarrhea may occur, although they are relatively uncommon.
  • Hypotension: In some cases, especially when starting treatment or with dose adjustments, blood pressure may drop too low, leading to symptoms of hypotension, including light-headedness and fainting.
  • Allergic Reactions: Allergic reactions, though rare, can occur. Symptoms may include skin rash, itching, swelling of the face or throat, and difficulty breathing. These should be reported immediately to a healthcare provider.

It’s essential for patients to discuss any side effects or concerns with their healthcare provider. The choice of medication and dosage should be tailored to the individual’s specific needs and monitored regularly. Overall, the benefits of effective blood pressure control often outweigh the potential side effects, but close communication with a healthcare provider is crucial for optimal management.

Frequently Asked Questions About Perindopril Arginine & Amlodipine Besilate Tablets:

Certainly, here are some frequently asked questions (FAQs) about Perindopril Arginine & Amlodipine Besilate Tablets:

  1. What are Perindopril Arginine & Amlodipine Besilate Tablets used for?

These tablets are primarily used to treat hypertension (high blood pressure). They help lower blood pressure and reduce the risk of cardiovascular complications associated with hypertension.

  1. How do Perindopril and Amlodipine work together to lower blood pressure?

Perindopril is an ACE inhibitor that relaxes blood vessels and reduces peripheral resistance, while amlodipine is a calcium channel blocker that directly relaxes blood vessel walls. Together, they provide a more comprehensive approach to blood pressure control.

  1. Can these tablets be used for other medical conditions besides hypertension?

While their primary indication is hypertension, healthcare providers may consider them for certain patients with other cardiovascular conditions, such as coronary artery disease and angina, to improve blood flow and reduce symptoms.

  1. How long does it take for these tablets to start lowering blood pressure effectively?

The onset of action can vary among individuals, but some people may begin to see a reduction in blood pressure within hours to days of starting treatment. However, it may take several weeks for the full antihypertensive effect to be realized.

  1. Are there any dietary restrictions or interactions to be aware of when taking these tablets?

Patients taking these tablets should generally follow a heart healthy diet, which may include reducing salt (sodium) intake. It’s essential to discuss any dietary concerns or potential drug interactions with your healthcare provider or pharmacist.

  1. Can these tablets be taken with other medications?

They can be taken with other medications, but it’s crucial to inform your healthcare provider about all the medications and supplements you are taking to avoid potential drug interactions.

  1. What should I do if I miss a dose of Perindopril Arginine & Amlodipine Besilate Tablets?

If you miss a dose, take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double dose to make up for a missed one.

  1. Can these tablets be used during pregnancy or while breastfeeding?

Pregnant or breastfeeding individuals should consult their healthcare provider before using these tablets, as they may not be suitable in all cases. Alternative medications or treatment plans may be considered.

  1. What are the potential side effects of Perindopril Arginine & Amlodipine Besilate Tablets?

Common side effects may include dizziness, edema (swelling), cough, headache, flushing, and gastrointestinal symptoms. Serious side effects are rare but can include allergic reactions and severe hypotension (low blood pressure).

  1. Is it safe to consume alcohol while taking these tablets?

It is generally safe to consume alcohol in moderation while taking these tablets, but excessive alcohol intake can affect blood pressure. It’s advisable to discuss alcohol consumption with your healthcare provider.

Patients should consult their healthcare provider or pharmacist for personalized information and guidance regarding the use of Perindopril Arginine & Amlodipine Besilate Tablets, including dosage, potential side effects, and any specific questions or concerns they may have.

As Perindopril Arginine & Amlodipine Besilate Tablets Exporters; We can cater to export business queries from the following geographies. We are exporting our Perindopril Arginine & Amlodipine Besilate Tablets product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Perindopril Arginine & Amlodipine Besilate Tablets Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Perindopril Arginine & Amlodipine Besilate Tablets, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593

GENERIC NAME OF THE MEDICINAL PRODUCT:

A. Perindopril Arginine & Amlodipine Besilate Tablets (5mg+5mg)
B. Perindopril Arginine & Amlodipine Besilate Tablets (5mg+10mg)
C. Perindopril Arginine & Amlodipine Besilate Tablets (10mg+5mg)
D. Perindopril Arginine & Amlodipine Besilate Tablets (10mg+10mg)
E. Perindopril Arginine & Amlodipine Besilate Tablets (3.5mg+2.5mg)
F. Perindopril Arginine & Amlodipine Besilate Tablets (7mg+5mg)
G. Perindopril Arginine & Amlodipine Besilate Tablets (14mg+10mg)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

A. Perindopril Arginine & Amlodipine Besilate Tablets (5mg+5mg)
Composition:
Each film-coated tablet contains:
Perindopril 3.395mg Corresponding to
Perindopril Arginine …………………….….5mg
Amlodipine Besilate ……………………6.935mg
Equivalent to Amlodipine……………5mg
Excipients…………………………………. q.s.
Colours: Titanium Dioxide USP


B. Perindopril Arginine & Amlodipine Besilate Tablets (5mg+10mg)
Composition:
Each film-coated tablet contains:
Perindopril 3.395mg Corresponding to
Perindopril Arginine …………………….….5mg
Amlodipine Besilate …………………… 13.870mg
Equivalent to Amlodipine……………10mg
Excipients…………………………………. q.s.
Colours: Iron Oxide Red

C. Perindopril Arginine & Amlodipine Besilate Tablets (10mg+5mg)
Composition:
Each film-coated tablet contains:
Perindopril 6.790mg Corresponding to
Perindopril Arginine …………………….….10mg
Amlodipine Besilate …………………… 6.935mg
Equivalent to Amlodipine……………5mg
Excipients…………………………………. q.s.
Colours: Iron Oxide Yellow

D. Perindopril Arginine & Amlodipine Besilate Tablets (10mg+10mg)
Composition:
Each film-coated tablet contains:
Perindopril 6.790mg Corresponding to
Perindopril Arginine …………………….….10mg
Amlodipine Besilate …………………… 13.870mg
Equivalent to Amlodipine……………10mg
Excipients…………………………………. q.s.
Colours: Iron Oxide Black

E. Perindopril Arginine & Amlodipine Besilate Tablets (3.5mg+2.5mg)
Composition:
Each film-coated tablet contains:
Perindopril 2.38mg Corresponding to
Perindopril Arginine …………………….….3.5mg
Amlodipine Besilate …………………… 3.47mg
Equivalent to Amlodipine……………2.5mg
Excipients…………………………………. q.s.
Colours: Brilliant Blue FCF

F. Perindopril Arginine & Amlodipine Besilate Tablets (7mg+5mg)
Composition:
Each film-coated tablet contains:
Perindopril 4.76mg Corresponding to
Perindopril Arginine …………………….….7mg
Amlodipine Besilate …………………… 6.935mg
Equivalent to Amlodipine……………5mg
Excipients…………………………………. q.s.
Colours: Sunset Yellow FCF

G. Perindopril Arginine & Amlodipine Besilate Tablets (14mg+10mg)
Composition:
Each film-coated tablet contains:
Perindopril 9.51mg Corresponding to
Perindopril Arginine …………………….….14mg
Amlodipine Besilate …………………… 13.870mg
Equivalent to Amlodipine……………10mg
Excipients…………………………………. q.s.
Colours: Indigo Carmine

THERAPEUTIC INDICATIONS:

Perindopril Arginine & Amlodipine Besilate Tablets used for lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Perindopril belongs to a class of drug known as ACE inhibitors and amlodipine belongs to a class of drug known as calcium channel blockers. Amlodipine relaxes (widens) blood vessels and improves blood flow.

DIRECTIONS:

Take this medicine at the same time each day. Taking it at the same time each day will have the best effect and will also help you remember when to take it.
This medicine should be taken in the morning before meal.

CAUTION & WARNING:

CAUTION: Do not throw away consumer package insert.
Swallow whole do not chew or crush.
WARNING: Do not skip/discontinue the dose for effective treatment.
Do not stop taking your medicine or change your dosage without consulting your doctor.
This medicine should not be used in children.
Keep out of the reach and sight of children.

STORAGE & DOSAGE:

Storage: Store protected from moisture at a temperature not exceeding 25°C.
Dosage: As directed by the Physician.
Your doctor will tell you how much of this medicine you should take.
The usual dose is 1 tablet once daily.
Note: Swallow your tablet with a glass of water.