Etoposide Injection USP 20mg/ml (250mg/12.5ml) (Lifepoyz)
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Etoposide Injection USP 20mg/ml (250mg/12.5ml) (Lifepoyz) Technical Specification:    

Product Name:Etoposide Injection USP 20mg/ml (250mg/12.5ml)
Brand Name:Lifepoyz
Strength:20mg/ml (100mg/5ml, 250mg/12.5ml, 500mg/25ml,1g/50ml)
Dosage Form:Liquid Injection
Packing:MULTI DOSE VIAL
Route of Administration:For I.V. use only – Must be diluted before
Pack Insert/Leaflet:PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics)
Regulatory Documents:COA, MOA, COPP, FSC, Stability Studies, GMP, CTD Dossier
Therapeutic use:Anti-Cancer
Indication: Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer.
Storage:Store at 20°C to 25°C (68° F to 77° F); excursions permitted to 15°C to 30°C (59° to 86° F) [see USP Controlled Room Temperature]. Protect from light. Do not freeze.

GENERIC NAME OF THE MEDICINAL PRODUCT:

  • Etoposide Injection USP 20mg/ml (250mg/12.5ml)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Etoposide Injection USP 20mg/ml (250mg/12.5ml)
    Each ml contains
    Etoposide USP………………………………………20mg
    Anhydrous citric acid…………………………….2mg
    Benzyl alcohol………………………………………30 mg
    Polysorbate tween 80……….…………………80mg
    Polyethylene glycol 300……………………….650mg
    Dehydrated alcohol…………………………….30.5%(v/v)

THERAPEUTIC INDICATION:

Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer.

PACKING:

20mg/ml

  • 100mg/5ml
  • 250mg/12.5ml
  • 500mg/25ml
  • 1g/50ml

DIRECTION OF USE:

For I.V. use only – Must be diluted before

See package insert for complete prescribing information.

CAUTION & WARNING:

CAUTION: This injection should not be used if it contains visible particulate matter.

WARNING: Cytotoxic Agent – To be sold by retail on the prescription of an Oncologist/ Cancer Hospital/ Institution.

WARNING: Severe lowering of blood counts (myelosuppression) may occur, which may cause or bleeding (sometimes fatal). Seek immediate medical attention if you develop symptoms of infection (fever, chills, persistent sore throat) or usually easy bruising or bleeding.

ETOPOSIDE IS AN ANTI-NEOPLASTIC DRUG FOR INTRAVENOUS OR ORAL USE, WHICH CAN BE USED ALONE OR IN COMBINATION WITH OTHER ONCOLYTIC DRUGS.

Not to be used in newly born or premature infants.

ANTINEOPLASTIC AGENT, ENZYME TOPOISOMERASE INHIBITOR

The container closure in not made with natural rubber latex.

FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.

Discard any unused solution.

Keep out of reach of children

STORAGE & DOSAGE:

Storage: Store at 20°C to 25°C (68° F to 77° F); excursions permitted to 15°C to 30°C (59° to 86° F) [see USP Controlled Room Temperature].

Protect from light. Do not freeze.

Dosage: As directed by the Oncologist.

Why Taj Pharmaceuticals?

Taj Pharma is your trusted choice for Etoposide Injection. With our unwavering commitment to quality, extensive experience in pharmaceuticals, and dedication to patient well-being, we are the preferred supplier for this vital cancer treatment. Explore our range of Etoposide Injection products today and experience the difference in healthcare excellence. When it comes to Etoposide Injection, Taj Pharma is the name you can rely on. Our long-standing reputation for excellence in pharmaceuticals is your assurance of quality and efficacy. Etoposide Injection is a critical component in the fight against cancer, and our commitment to stringent quality standards ensures that you receive the highest standard of care. With decades of experience in pharmaceutical manufacturing and distribution, Taj Pharma is your trusted partner in the journey to better health. Explore our extensive range of Etoposide Injection products today, and let us be your beacon of hope and healing. Your well-being is our paramount concern.

What is Etoposide Injection and its use?

Etoposide Injection is a medication used in cancer treatment, specifically as part of chemotherapy regimens. It contains the active ingredient etoposide, which belongs to a class of drugs known as topoisomerase inhibitors. Etoposide is available in both oral and injectable forms, and the injectable form is often used in clinical settings for cancer treatment.

Use of Etoposide Injection:

  • Cancer Treatment: Etoposide Injection is primarily used to treat various types of cancer. It is often prescribed for conditions such as:
    Small Cell Lung Cancer: Etoposide is a key component of chemotherapy regimens for small cell lung cancer, both as a firstline and secondline treatment.
    Testicular Cancer: It is sometimes used in combination with other chemotherapy drugs to treat testicular cancer.
    Various Lymphomas: Etoposide may be part of the treatment plan for certain types of lymphomas, such as Hodgkin’s lymphoma.
    Various Solid Tumors: Etoposide can also be prescribed for other types of solid tumors, including ovarian cancer, neuroblastoma, and certain types of sarcomas.
  • Bone Marrow Disorders: In some cases, Etoposide Injection may be used to treat certain nonmalignant conditions involving the bone marrow, such as hemophagocytic lymphohistiocytosis (HLH).

Etoposide works by interfering with the DNA replication process in cancer cells. It inhibits the action of an enzyme called topoisomerase II, which is responsible for unwinding and rewinding DNA strands during cell division. By disrupting this process, Etoposide prevents the cancer cells from dividing and growing, ultimately leading to their death.

The use of Etoposide Injection is typically determined by an oncologist or healthcare provider based on the type and stage of cancer, as well as the patient’s overall health and individual treatment plan. It is administered intravenously by trained healthcare professionals in a clinical setting, and the dosage and treatment schedule are carefully tailored to the specific needs of the patient. Like many chemotherapy drugs, Etoposide can have side effects, which should be discussed with a healthcare provider before starting treatment.

How does Etoposide Injection Work?

Etoposide Injection works by interfering with the DNA replication process in rapidly dividing cells, particularly cancer cells. It belongs to a class of chemotherapy drugs known as topoisomerase inhibitors. To understand how Etoposide works, it’s helpful to know the basics of DNA replication and cell division:

  • DNA Replication: When a cell divides, it must make a copy of its DNA to pass on genetic information to the new cells. DNA replication is a highly regulated process that involves unwinding the DNA double helix, copying the genetic code, and then rewinding the DNA.
  • Topoisomerases: Topoisomerases are enzymes that play a crucial role in DNA replication. They help by cutting the DNA strands to relieve the tension caused by the unwinding process. After cutting, they allow the DNA to unwind, and then they reseal the strands once replication is complete.

Etoposide works by specifically inhibiting a type of topoisomerase known as topoisomerase II. Here’s how Etoposide interferes with this process:

  • DNA Cleavage: Etoposide binds to topoisomerase II and stabilizes the enzyme’s interaction with DNA. This prevents the enzyme from resealing the DNA strands after cutting.
  • DNA Strand Breaks: As a result of this stabilization, topoisomerase II remains attached to the DNA, creating breaks in the DNA strands.
  • Cell Cycle Arrest: When the DNA strands are broken and cannot be properly repaired, the affected cells cannot progress through the cell cycle. This leads to cell cycle arrest, preventing the cancer cells from dividing and proliferating.
  • Cell Death: The accumulation of DNA strand breaks and the inability of cancer cells to divide ultimately result in cell death. This is the desired outcome in cancer treatment, as it helps to shrink or eliminate tumors.

Etoposide’s action is selective for rapidly dividing cells, such as cancer cells, because these cells are more reliant on topoisomerase II for DNA replication than normal, non-dividing cells. While Etoposide targets cancer cells, it can also affect some healthy cells, leading to chemotherapy-related side effects.

Benefits and Side effects of Etoposide Injection?

Etoposide Injection is a chemotherapy medication primarily used to treat various types of cancer. Like many chemotherapy drugs, it offers potential benefits in treating cancer, but it may also be associated with side effects. Here are some of the benefits and potential side effects of Etoposide Injection:

Benefits:

  • Cancer Treatment: Etoposide Injection is an effective treatment for several types of cancer, including small cell lung cancer, testicular cancer, certain lymphomas, and other solid tumors. It can help to shrink tumors, slow their growth, or eliminate cancer cells.
  • Part of Combination Therapy: Etoposide is often used in combination with other chemotherapy drugs or treatment modalities to enhance its effectiveness in cancer treatment.
  • Diverse Applications: Etoposide may be prescribed for a range of cancers, making it a versatile chemotherapy option for oncologists.
  • Adjunct to Radiation Therapy: In some cases, Etoposide may be used in combination with radiation therapy to enhance its effectiveness in killing cancer cells.

Side Effects:

It’s important to note that the side effects of Etoposide Injection can vary from person to person, and not everyone will experience all of these side effects. The severity of side effects may also depend on the dosage and duration of treatment. Common side effects may include:

  • Nausea and Vomiting: Nausea and vomiting are common side effects of Etoposide treatment. Medications known as antiemetics can often help manage these symptoms.
  • Bone Marrow Suppression: Etoposide can reduce the production of blood cells in the bone marrow, leading to conditions like anemia (low red blood cell count), thrombocytopenia (low platelet count), and neutropenia (low white blood cell count). This can increase the risk of infections, bleeding, and fatigue.
  • Hair Loss: Temporary hair loss or thinning is a common side effect of chemotherapy, including Etoposide.
  • Mouth Sores: Some individuals may develop mouth sores or ulcers during Etoposide treatment, which can be painful.
  • Loss of Appetite: Chemotherapy can lead to a loss of appetite and changes in taste preferences.
  • Fatigue: Many people experience fatigue during chemotherapy, which can be mild to severe.
  • Allergic Reactions: Although rare, allergic reactions to Etoposide can occur. Signs may include rash, itching, swelling, and difficulty breathing.
  • Liver Function Changes: Etoposide can affect liver function, leading to elevated liver enzymes. This is typically monitored during treatment.
  • Kidney Function Changes: In some cases, Etoposide may affect kidney function, leading to changes in urine output and kidney function tests.
  • Infertility: Etoposide can affect fertility, and patients of reproductive age should discuss fertility preservation options with their healthcare team before treatment.

It’s essential for individuals receiving Etoposide Injection to have regular communication with their oncologist and healthcare team. They can help manage side effects and provide guidance on how to minimize discomfort and maintain overall well-being during cancer treatment. In some cases, adjustments to the treatment plan or supportive medications may be recommended to improve the patient’s quality of life during therapy.

Frequently asked questions (FAQs) about Etoposide Injection:

  1. What is Etoposide Injection?

Etoposide Injection is a chemotherapy medication containing the active ingredient etoposide. It is used to treat various types of cancer.

  1. What types of cancer are treated with Etoposide Injection?

Etoposide is used to treat cancers such as small cell lung cancer, testicular cancer, certain lymphomas, and various solid tumors.

  1. How is Etoposide Injection administered?

Etoposide Injection is administered intravenously (IV) by a healthcare professional in a clinical setting, typically as part of a chemotherapy regimen.

  1. How does Etoposide Injection work to treat cancer?

Etoposide interferes with the DNA replication process in rapidly dividing cancer cells, preventing them from dividing and ultimately leading to cell death.

  1. What are the potential side effects of Etoposide Injection?

Common side effects may include nausea, vomiting, bone marrow suppression (anemia, thrombocytopenia, neutropenia), hair loss, mouth sores, fatigue, and changes in liver or kidney function. Allergic reactions are rare but possible.

  1. How long is Etoposide Injection treatment typically given?

The duration of Etoposide treatment varies depending on the type and stage of cancer, as well as the individual’s response to therapy. Treatment may involve multiple cycles.

  1. Are there any precautions to take during Etoposide treatment?

Patients receiving Etoposide should follow their healthcare provider’s recommendations, maintain good hydration, and report any side effects promptly. Discuss fertility preservation options if of concern.

  1. Can Etoposide Injection be used during pregnancy or breastfeeding?

Etoposide is generally not recommended during pregnancy, and breastfeeding is typically discouraged while undergoing chemotherapy. Discuss fertility and family planning with your healthcare team.

  1. Can I continue my normal activities during Etoposide treatment?

Fatigue is a common side effect, so you may need to adjust your activities. Consult your healthcare provider for guidance on maintaining your daily routines.

  1. Can Etoposide Injection cure cancer?

The effectiveness of Etoposide in treating cancer depends on various factors, including the type and stage of cancer and the individual’s response to treatment. It may be used to shrink tumors, slow their growth, or achieve remission.

  1. Are there any dietary restrictions during Etoposide treatment?

Some patients may experience changes in taste preferences and appetite. Maintaining good nutrition is important, so working with a registered dietitian or nutritionist may be beneficial.

  1. Can I take other medications or supplements while on Etoposide treatment?

It’s essential to inform your healthcare provider about all medications and supplements you are taking, as there may be interactions or contraindications with Etoposide.

As Etoposide Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Etoposide Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Etoposide Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Etoposide Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274

GENERIC NAME OF THE MEDICINAL PRODUCT:

Etoposide Injection USP 20mg/ml (100mg/5ml, 250mg/12.5ml, 500mg/25ml,1g/50ml)

QUALITATIVE AND QUANTITATIVE COMPOSITION:

Etoposide Injection USP 20mg/ml (100mg/5ml, 250mg/12.5ml, 500mg/25ml,1g/50ml)
Each ml contains
Etoposide USP………………………………………20mg
Anhydrous citric acid…………………………….2mg
Benzyl alcohol………………………………………30 mg
Polysorbate tween 80..........…………………80mg
Polyethylene glycol 300……………………….650mg
Dehydrated alcohol…………………………….30.5%(v/v)

THERAPEUTIC INDICATION:

Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer.

PACKING:

20mg/ml
1) 100mg/5ml
2) 250mg/12.5ml
3) 500mg/25ml
4) 1g/50ml

DIRECTION OF USE:

For I.V. use only – Must be diluted before
See package insert for complete prescribing information.

CAUTION & WARNING:

CAUTION: This injection should not be used if it contains visible particulate matter.
WARNING: Cytotoxic Agent - To be sold by retail on the prescription of an Oncologist/ Cancer Hospital/ Institution.
WARNING: Severe lowering of blood counts (myelosuppression) may occur, which may cause or bleeding (sometimes fatal). Seek immediate medical attention if you develop symptoms of infection (fever, chills, persistent sore throat) or usually easy bruising or bleeding.
ETOPOSIDE IS AN ANTI-NEOPLASTIC DRUG FOR INTRAVENOUS OR ORAL USE, WHICH CAN BE USED ALONE OR IN COMBINATION WITH OTHER ONCOLYTIC DRUGS.
Not to be used in newly born or premature infants.
ANTINEOPLASTIC AGENT, ENZYME TOPOISOMERASE INHIBITOR
The container closure in not made with natural rubber latex.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.
Discard any unused solution.
Keep out of reach of children

STORAGE & DOSAGE:

Storage: Store at 20°C to 25°C (68° F to 77° F); excursions permitted to 15°C to 30°C (59° to 86° F) [see USP Controlled Room Temperature].
Protect from light. Do not freeze.
Dosage: As directed by the Oncologist.