Deferasirox Dispersible Tablets 500mg (Defrataj)

How do Deferasirox Dispersible Tablets work?

Deferasirox Dispersible Tablets contain the active ingredient Deferasirox, which is an iron-chelating agent. Iron chelation is a process where a chemical compound binds to excess iron in the body, forming a complex that can be eliminated through urine and feces. This helps to reduce the buildup of iron in various organs and tissues, which can occur due to conditions like beta-thalassemia, other chronic anemias, and frequent blood transfusions. Deferasirox works by binding to the excess iron present in the bloodstream and inside cells. Once Deferasirox forms a complex with iron, it becomes soluble and can be excreted from the body through the kidneys (in urine) and the intestines (in feces).
The process can be described in these steps:

• Binding to Iron: Deferasirox has a high affinity for iron, meaning it readily binds to iron molecules in the body.
• Formation of Complexes: Once bound to iron, Deferasirox forms stable complexes with iron ions. These complexes are water-soluble and can be easily eliminated from the body.
• Excretion: The complexes formed between Deferasirox and iron are then filtered by the kidneys and excreted through urine. Additionally, some of the complexes are transported through the intestines and excreted in feces.
• Reduction of Iron Levels: As Deferasirox continues to bind to and remove excess iron from the body, the overall iron levels in organs and tissues decrease. This reduction is important in preventing iron overload-related complications that can affect organs like the heart, liver, and endocrine glands.

By effectively binding to excess iron and aiding its elimination, Deferasirox helps manage iron overload and reduces the risk of organ damage and other associated health issues.

Benefits of Deferasirox Dispersible Tablets:

• Effective Iron Chelation: Deferasirox Dispersible Tablets effectively bind to excess iron in the body, aiding in its removal and preventing iron overload-related complications.
• Convenience: The dispersible tablet form offers convenience, especially for individuals who have difficulty swallowing traditional tablets.
• Reduced Organ Damage: By lowering iron levels, Deferasirox helps reduce the risk of organ damage, particularly in organs like the heart, liver, and endocrine glands.
• Improved Quality of Life: Managing iron overload with Deferasirox Dispersible Tablets can lead to an improved quality of life for individuals with conditions like beta-thalassemia, as it helps prevent health issues associated with excessive iron accumulation.
• Flexible Administration: The dispersible tablet can be dissolved in liquid, allowing for more flexible administration and improved patient compliance.
• Global Reputation: Taj Pharmaceuticals’ reputation for quality and commitment to healthcare excellence adds to the reliability of their Deferasirox Dispersible Tablets.

Side Effects of Deferasirox Dispersible Tablets:

• Gastrointestinal Distress: Common side effects may include nausea, vomiting, abdominal pain, and diarrhea. These symptoms can usually be managed with proper dosing adjustments and guidance from a healthcare provider.
• Skin Rash: Some individuals might experience skin rash or itching as a side effect. It’s important to report any skin-related issues to a healthcare professional.
• Kidney Effects: Deferasirox can affect kidney function in some cases, leading to changes in urine output and kidney function tests. Regular monitoring is essential to catch any kidney-related issues early.
• Liver Effects: Liver enzyme levels may be elevated in some individuals using Deferasirox, which could indicate liver involvement. Monitoring liver function is crucial during treatment.
• Auditory and Visual Changes: Rarely, Deferasirox can cause auditory and visual disturbances. Any changes in hearing or vision should be reported to a healthcare provider.
• Allergic Reactions: In rare cases, individuals may experience allergic reactions, which could include symptoms like rash, swelling, and difficulty breathing. Seek medical attention if such reactions occur.
• Bone Marrow Suppression: Deferasirox can affect bone marrow function in some individuals, leading to decreases in red and white blood cell counts and platelet levels.
• Renal and Hepatic Failure: In rare instances, severe renal (kidney) or hepatic (liver) failure can occur. Close monitoring and prompt reporting of any symptoms are essential.