Chlorambucil Tablets BP 5mg (Leuzetra)

Chlorambucil Tablets BP 5mg (Leuzetra) Technical Specification:

GENERIC NAME OF THE MEDICINAL PRODUCT:

• Chlorambucil Tablets BP 5mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

• Chlorambucil Tablets BP 5mg
  Each film-coated tablet contains:
  Chlorambucil BP………….……..5 mg
  Excipients…………………………..q.s.
  Colours: Iron Oxide Red

THERAPEUTIC INDICATIONS:

Chlorambucil is used treat a certain type of chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Chlorambucil is also used to treat non-Hodgkin’s lymphoma (NHL) and Hodgkin’s disease (types of cancer that begin in certain white blood cells that normally fight infection).

CAUTION & WARNING:

Caution: It is dangerous to take this preparation except under medical supervision.
Warning: Cytotoxic Agent: To be sold by retail on the prescription of an oncologist/ Cancer Hospital/ Institution only.
Warning: Cytotoxic: To be supplied against demand from Cancer Hospitals, Institutions and against prescription of a Cancer Specialist only.
Do not take in larger doses or more frequently or for a longer time than specifically directed by the physician. Periodic blood counts are necessary to determine proper dose and to avoid its effects.
Dispense in tight container as defined in the USP.
Keep out of reach and sight of children.
Swallow complete tablet, do not crush or chew.

STORAGE & DOSAGE:

Storage: Store between 2°C to 8°C (36° F to 46° F). Protect from light and moisture.
Dosage: As directed by Oncologist.
For Oral use. Read the package insert before use.

Why Taj pharmaceuticals?

Taj Pharmaceuticals: A Trusted Source for Chlorambucil Tablets
Taj Pharmaceuticals has established itself as a prominent player in the pharmaceutical industry, known for its unwavering commitment to healthcare excellence. Central to their offerings is Chlorambucil Tablets, a critical medication employed in the treatment of various medical conditions. What sets Taj Pharmaceuticals apart is their steadfast dedication to quality, innovation, and above all, the well-being of patients.
Quality stands as the cornerstone of Taj Pharmaceuticals’ pharmaceutical legacy. Each Chlorambucil Tablet bearing their name undergoes stringent quality control measures, ensuring it adheres to the highest standards of safety and effectiveness. This commitment to upholding exceptional quality not only sets them apart but also forms the bedrock of their pharmaceutical prowess.
Innovation is at the heart of Taj Pharmaceuticals’ operations. They do not merely follow industry trends; they set them. They are pioneers in healthcare innovation, continuously seeking ways to elevate medical solutions for the betterment of individuals. Chlorambucil Tablets exemplify their dedication to pushing the boundaries of innovation within the pharmaceutical realm.
When one chooses Taj Pharmaceuticals for Chlorambucil Tablets, they are entering into a partnership focused on their journey to health and recovery. The well-being of individuals takes precedence, and Taj Pharmaceuticals takes immense pride in being a dependable source of this vital medication, serving both healthcare professionals and patients alike.
Their vision extends far beyond geographical confines. Taj Pharmaceuticals firmly believes that access to quality healthcare should transcend borders. Their global reach ensures that individuals worldwide have access to high-quality Chlorambucil Tablets. They are committed to dismantling barriers to healthcare accessibility, making quality treatment universally attainable.
In the pursuit of health and well-being, Taj Pharmaceuticals stands as an unwavering ally. Placing trust in their legacy of excellence, they become a partner in the journey towards improved health and vitality. Health is their mission, and they are resolute in their dedication and integrity as they serve individuals on their path to wellness.

What is Chlorambucil Tablets and its uses?

Chlorambucil Tablets: Versatile Uses in Medical Treatment
Chlorambucil, available in tablet form, plays a crucial role in medical therapeutics across various conditions. Its primary uses encompass the treatment of specific cancers and immune system disorders, making it a valuable medication in the healthcare arsenal.
One of its prominent applications is in Chronic Lymphocytic Leukemia (CLL), a type of cancer that affects white blood cells. Chlorambucil acts as an alkylating agent, disrupting the DNA of cancer cells and inhibiting their uncontrolled proliferation. By reducing the number of malignant cells in the blood and bone marrow, it contributes to the management and potential remission of CLL.
Beyond CLL, Chlorambucil finds utility in managing certain forms of Non-Hodgkin Lymphoma, another lymphatic system cancer. Its mechanism of action remains consistent – impeding the growth of cancerous lymphocytes, a process pivotal in controlling the disease.
Chlorambucil also extends its therapeutic reach to immune system disorders. In autoimmune conditions where the body erroneously attacks its own tissues, this medication assumes the role of an immunosuppressive agent. This function is especially vital in alleviating the suffering of patients with autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus, where an overactive immune response is tamed.
In cases of nephrotic syndrome, a kidney disorder characterized by excessive protein loss in urine, Chlorambucil may be considered when other treatment avenues prove insufficient. It steps in to address this challenging condition.
While less common, Chlorambucil may also be deployed in the management of severe rheumatoid arthritis resistant to other therapies. By suppressing immune system activity, it mitigates inflammation and joint damage, enhancing the quality of life for patients.
However, it is imperative to underscore that Chlorambucil is a potent medication with potential side effects, demanding close monitoring by healthcare professionals. Treatment decisions must be made judiciously, carefully weighing the benefits against the associated risks for each patient and medical condition. As dosages and treatment duration vary, adherence to healthcare provider instructions remains paramount for patients receiving Chlorambucil Tablets. Prompt reporting of any side effects or concerns ensures safe and effective therapy.

How does Chlorambucil Tablets Work?

Chlorambucil Tablets are recognized for their potent therapeutic effects, and their mechanism of action revolves around their role as alkylating agents. This class of drugs is distinguished by their ability to interact with the DNA within cells, with Chlorambucil being particularly effective in this regard.

Upon administration, Chlorambucil undergoes metabolic processes within the body, eventually yielding highly reactive intermediates. These intermediates possess the capability to form covalent bonds with DNA molecules. When they bind to the DNA, they induce structural alterations in the DNA strands within the cell’s nucleus. This interference disrupts the normal DNA structure, impeding crucial processes like replication and repair.

The consequences of this interference are profound. It leads to a disruption in the cell cycle—a series of stages that cells typically go through, including growth, DNA replication, and division. Chlorambucil’s action effectively halts this cycle, preventing affected cells from progressing to the division phase. The cells, unable to divide and replicate, are compelled to undergo programmed cell death, a process known as apoptosis. This programmed cell death is particularly advantageous in cancer treatment, as it reduces the number of cancerous cells in the body.

What sets Chlorambucil apart is its selective targeting. It exhibits an affinity for rapidly dividing cells, which encompasses cancer cells and certain immune system cells. This selectivity allows the drug to focus its effects on the cells that require control while sparing healthy, non-dividing cells.

In essence, Chlorambucil Tablets work by acting as alkylating agents that disrupt DNA structure and halt the cell cycle in rapidly dividing cells. This interference ultimately leads to programmed cell death, making Chlorambucil an effective medication in the treatment of conditions like cancer and immune system disorders. However, it is important to note that Chlorambucil’s impact can extend to healthy cells, underscoring the need for careful monitoring by healthcare professionals to balance its therapeutic benefits and potential side effects in each patient’s unique medical context.

Benefits of Chlorambucil Tablets:

Chlorambucil Tablets offer a range of therapeutic benefits, making them valuable in various medical scenarios. Firstly, they are highly effective in the treatment of cancer, particularly chronic lymphocytic leukemia (CLL) and certain types of non-Hodgkin lymphoma. By disrupting the DNA structure within cancer cells and halting their uncontrolled division, Chlorambucil helps control and potentially induce remission in these malignancies.

Beyond cancer treatment, Chlorambucil demonstrates its versatility by serving as an immunosuppressive agent. This property is vital in the management of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. By tempering the overactive immune response responsible for these conditions, Chlorambucil alleviates symptoms and enhances patients’ quality of life.

In the realm of kidney disorders, Chlorambucil offers hope for individuals suffering from nephrotic syndrome, a condition characterized by excessive protein loss in urine. When other treatments prove inadequate, Chlorambucil may be considered to address this challenging condition.

Side Effects of Chlorambucil Tablets:

While Chlorambucil Tablets bring substantial benefits, they are not without their share of potential side effects. These side effects necessitate careful monitoring by healthcare professionals to ensure patient safety.

One of the primary concerns is bone marrow suppression, which can lead to anemia, leukopenia (reduced white blood cell count), and thrombocytopenia (reduced platelet count). These blood-related issues can increase the risk of infections, bleeding, and fatigue and must be closely managed.

Gastrointestinal side effects, including nausea and vomiting, are common with Chlorambucil use. Fortunately, healthcare providers can prescribe medications to help manage these symptoms and improve patients’ comfort.

Chlorambucil may also increase the susceptibility to infections due to its impact on white blood cell production. Patients are advised to take precautions to minimize the risk of exposure to contagious illnesses and promptly report any signs of infection to their healthcare provider.

Other side effects include hair loss (alopecia), gastrointestinal problems like diarrhea and abdominal pain, and potential effects on the liver and kidneys, which may require regular monitoring through blood tests.

Lastly, long-term use of Chlorambucil may carry a slightly increased risk of developing secondary cancers, such as acute leukemia. However, it’s important to note that the benefits of treating the primary condition often outweigh this risk.

In conclusion, Chlorambucil Tablets offer valuable benefits in cancer treatment, autoimmune disorders, and nephrotic syndrome management. However, their potent effects also come with potential side effects that require vigilant monitoring. Healthcare professionals play a critical role in optimizing the therapeutic benefits of Chlorambucil while minimizing any adverse effects, ensuring the well-being of patients undergoing this treatment.

Frequently Asked Questions About Chlorambucil Tablets:

1. What are Chlorambucil Tablets used for?

Chlorambucil Tablets are primarily used in the treatment of certain cancers, including Chronic Lymphocytic Leukemia (CLL) and specific types of non-Hodgkin lymphoma. They are also employed as immunosuppressive therapy in autoimmune disorders and in the management of nephrotic syndrome when other treatments are ineffective.

2. How does Chlorambucil work in cancer treatment?

Chlorambucil acts as an alkylating agent, disrupting the DNA within rapidly dividing cancer cells. This interference inhibits cell division and leads to cell death, helping control and potentially induce remission in cancer.

3. Are there any common side effects of Chlorambucil Tablets?

Yes, common side effects include nausea, vomiting, bone marrow suppression (resulting in anemia, leukopenia, and thrombocytopenia), increased susceptibility to infections, hair loss, gastrointestinal issues like diarrhea, and potential effects on the liver and kidneys. Monitoring by healthcare professionals is crucial to manage these side effects.

4. Can Chlorambucil cause secondary cancers?

Long-term use of Chlorambucil may carry a slightly increased risk of developing secondary cancers, such as acute leukemia. However, the benefits of treating the primary condition often outweigh this risk.

5. How should Chlorambucil Tablets be taken?

The dosage and duration of Chlorambucil treatment vary depending on the specific medical condition and the patient’s response. It is essential to follow the healthcare provider’s instructions carefully and report any side effects promptly.

6. Is Chlorambucil safe during pregnancy and breastfeeding?

Chlorambucil is known to be harmful to developing fetuses, and its use is generally avoided during pregnancy. It is also not recommended during breastfeeding, as it may be excreted in breast milk. Women of childbearing age should use effective contraception while taking Chlorambucil.

7. Can I consume alcohol while taking Chlorambucil Tablets?

It is advisable to avoid alcohol while taking Chlorambucil, as it may exacerbate some of the medication’s side effects and potentially interact with its metabolism.

8. Are there any drug interactions with Chlorambucil?
   

Chlorambucil can interact with certain medications, so it’s important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking. This includes over-the-counter drugs.

9. How often should I have medical check-ups while on Chlorambucil treatment?

Regular medical check-ups are crucial to monitor your overall health, blood cell counts, and any potential side effects. The frequency of these check-ups will be determined by your healthcare provider.

10. Can I discontinue Chlorambucil treatment if I feel better?

It is essential to follow the prescribed treatment plan and not discontinue Chlorambucil without consulting your healthcare provider. Discontinuing treatment prematurely may impact its effectiveness in managing your medical condition. Always consult with your healthcare team before making any changes to your medication regimen.

As Chlorambucil Tablets Exporters; We can cater to export business queries from the following geographies. We are exporting our Chlorambucil Tablets product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Chlorambucil Tablets Regulatory Documents:

• Certificate of Analysis (COA)
• Method of Analysis (MOA)
• Stability Data (Accelerated stability / Long-term stability / Zone 4b)
• CTD Dossier / ACTD Dossiers / eCTD Dossiers
• Certificate of Pharmaceuticals Product (COPP)
• Free Sale Certificate (FSC)

Contact the most reliable manufacturer of  Chlorambucil Tablets, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274