Ceftriaxone & Sulbactam for Injection 1.5gm Technical Specification:

Product Name:Ceftriaxone & Sulbactam for Injection 1.5gm
Brand Name:CEPTRATAJ -S
Strength:1.5gm, 750mg, 375mg, 187.5mg
Dosage Form:Dry Powder Injection (Sterile)
Packing:Vial + WFI in Tray
Route of Administration:For I.M./ I.V. use
Pack Insert/Leaflet:PIL (Patient Information Leaflet)
Documents:COA, MOA, Product Permission, Stability Studies, GMP
Therapeutic use:β-lactam Antibiotic, Anti-bacterial & Cephalosporin.
Indication: Ceftriaxone & Sulbactam for Injection is indicated in Sepsis, Meningitis, Abdominal Infections, infections of the Bones, Renal, UTIs, Pneumonia, Ear, Nose, and Throat Infections, and uncomplicated gonorrhea.
Storage:Store Below 25°C Protect from light & moisture

GENERIC NAME OF MEDICINAL PRODUCT:

  • Ceftriaxone & Sulbactam for Injection 1.5gm

QUALITATIVE AND QUANTITATIVE COMPOSITION:

  • Ceftriaxone & Sulbactam for Injection 1.5gm
    Each vial contains:
    Ceftriaxone Sodium IP (Sterile)
    Eq. to Anhydrous Ceftriaxone …………1000mg
    Sulbactam Sodium IP (Sterile)
    Eq. to Anhydrous Sulbactam …………500mg
    Sterile water for Injection IP ……….……… 10ml

THERAPEUTIC INDICATION:

Ceftriaxone & Sulbactam for Injection is indicated in Sepsis, Meningitis, Abdominal Infections, infections of the Bones, Renal, UTIs, Pneumonia, Ear, Nose, and Throat Infections, and uncomplicated gonorrhea.

DIRECTION OF USE:

Reconstitute with 10 ml of Sterile Water for Injection IP supplied with pack as required.

Prick the ampoule of Sterile Water for Injection IP only once and discard the unused portion.

Reconstituted solution should be use immediately after preparation.

CAUTION AND SCHEDULE:

CAUTION: If any foreign particle is visible in the vial after dissolving the contents, please do not use the solution.

FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.

SCHEDULE: SCHEDULE ‘H1’ DRUG:

-It is dangerous to take this preparation except in accordance with the medical advice.

-Not to be sold by retail without the prescription of Registered Medical Practitioner.

KEEP OUT OF REACH OF CHILDREN.

*Not to be sold without water for Injection.

STORAGE AND DOSAGE:

STORAGE:  Store Below 25°C.
Protect from light & moisture.
Do not freeze.

DOSAGE:  As directed by Physician.

Note: Water for Injection IP Ampoule is not manufactured by us.

Why Taj Pharmaceuticals?

Taj Pharmaceuticals is a reputable and well-established pharmaceutical company known for its unwavering commitment to quality, innovation, and the well-being of patients. One of its noteworthy offerings is Ceftriaxone & Sulbactam for Injection, and Taj Pharmaceuticals has built a strong reputation in the pharmaceutical industry for several key reasons. Firstly, Taj Pharmaceuticals boasts state-of-the-art manufacturing facilities that adhere to stringent quality control standards and regulatory guidelines. These facilities are equipped with the latest technology and maintained to the highest industry standards to ensure the production of safe and effective medications. The company’s dedication to research and development is another standout feature. Taj Pharmaceuticals invests significantly in scientific innovation to continuously enhance its products and develop cutting-edge healthcare solutions. This commitment to advancing medical science ensures that patients receive the best possible treatments. Quality assurance is a fundamental aspect of Taj Pharmaceuticals’ operations. At every stage of the manufacturing process, from sourcing raw materials to production and final product testing, rigorous quality assurance protocols are followed. This meticulous approach guarantees the safety and efficacy of their pharmaceutical products, including Ceftriaxone & Sulbactam for Injection.

Taj Pharmaceuticals’ global reach is also notable. The company exports its pharmaceutical products to numerous countries worldwide, contributing to improved healthcare access for people across the globe. This international presence reflects Taj Pharmaceuticals’ commitment to making high-quality medications accessible to all, regardless of geographic location. Above all, Taj Pharmaceuticals places patient health and safety as its top priority. The company’s products are designed to provide effective treatment while minimizing potential side effects, ensuring that patients can trust in the quality and safety of medications like Ceftriaxone & Sulbactam for Injection. With its outstanding track record and unwavering dedication to healthcare excellence, Taj Pharmaceuticals continues to be a trusted choice for healthcare providers and patients alike.

What is Ceftriaxone & Sulbactam for Injection and its uses:

Ceftriaxone & Sulbactam for Injection is a combination medication used in the field of medicine for specific therapeutic purposes. It is composed of two active ingredients: ceftriaxone, a potent antibiotic, and sulbactam, a beta-lactamase inhibitor. This combination is designed to provide a synergistic effect in treating a variety of bacterial infections.

The primary uses of Ceftriaxone & Sulbactam for Injection include:
  • Treatment of Infections: This medication is commonly prescribed to combat a broad spectrum of bacterial infections. It is effective against both Gram-positive and Gram-negative bacteria. Common infections treated with Ceftriaxone & Sulbactam include respiratory tract infections, skin and soft tissue infections, urinary tract infections, and intra-abdominal infections.
  • Intravenous Administration: Ceftriaxone & Sulbactam for Injection is administered intravenously (IV), which means it is typically used in a hospital or clinical setting under the supervision of healthcare professionals. This route allows for rapid absorption and delivery of the medication into the bloodstream.
  • Combating Beta-Lactamase Resistance: The inclusion of sulbactam in this medication serves an important role. Sulbactam is a beta-lactamase inhibitor that helps to counteract bacterial resistance. Beta-lactamases are enzymes produced by some bacteria that can inactivate antibiotics like ceftriaxone. Sulbactam inhibits these enzymes, enhancing the effectiveness of ceftriaxone.
  • Serious Infections: Ceftriaxone & Sulbactam is often reserved for the treatment of serious or complicated infections, especially when the specific causative bacteria are not yet identified. It can be a critical choice in empiric therapy, where immediate treatment is needed before laboratory results are available.
  • Meningitis: Ceftriaxone & Sulbactam for Injection is also used in the treatment of bacterial meningitis, a serious infection affecting the membranes covering the brain and spinal cord.
  • Preoperative Prophylaxis: In some cases, this medication may be used to prevent infections before surgery, particularly in procedures where there is a high risk of bacterial contamination.

It is important to note that Ceftriaxone & Sulbactam for Injection should only be administered under the guidance and supervision of a qualified healthcare provider. The choice of antibiotic therapy, including the use of combination medications like this one, should be based on a thorough assessment of the patient’s condition, susceptibility of the infecting bacteria, and local antibiotic resistance patterns. Additionally, it is crucial to complete the full course of treatment as prescribed by a healthcare professional to ensure the infection is adequately eradicated and to minimize the development of antibiotic resistance.

How Does Ceftriaxone & Sulbactam for Injection Work?

Ceftriaxone & Sulbactam for Injection combines two active ingredients, ceftriaxone and sulbactam, to effectively treat bacterial infections. To understand how it works, let’s break down the actions of each component:

  • Ceftriaxone (Third-generation Cephalosporin):
    Bacterial Cell Wall Synthesis Inhibition: Ceftriaxone belongs to a class of antibiotics known as cephalosporins. Like other cephalosporins, it works by interfering with the synthesis of the bacterial cell wall. Bacterial cells have a protective outer layer, the cell wall, which is essential for their structure and stability. Ceftriaxone disrupts the formation of this cell wall by binding to specific proteins called penicillin-binding proteins (PBPs). By inhibiting these PBPs, ceftriaxone weakens the cell wall, making it more susceptible to rupture.
  • Sulbactam (Beta-Lactamase Inhibitor):
    Beta-Lactamase Inhibition: Many bacteria produce enzymes called beta-lactamases (or beta-lactamases) that can destroy or inactivate beta-lactam antibiotics, including cephalosporins like ceftriaxone. Sulbactam is a beta-lactamase inhibitor, which means it can neutralize the harmful effects of beta-lactamases. It does this by binding to and deactivating these enzymes. By inhibiting beta-lactamases, sulbactam helps protect ceftriaxone from degradation, allowing it to remain active against bacteria.
  • Combination Synergistic Effect:
    When ceftriaxone and sulbactam are administered together as Ceftriaxone & Sulbactam for Injection, they work synergistically to combat bacterial infections more effectively than ceftriaxone alone. This combination is particularly useful when dealing with bacterial strains that produce beta-lactamases, as sulbactam helps prevent these enzymes from inactivating ceftriaxone. This dual-action approach enhances the overall antibacterial activity of the medication, expanding its spectrum of coverage and improving its effectiveness against a wide range of bacteria.

Ceftriaxone & Sulbactam for Injection fights bacterial infections by inhibiting the synthesis of the bacterial cell wall (ceftriaxone) and neutralizing bacterial enzymes that can inactivate antibiotics (sulbactam). This combination helps overcome antibiotic resistance mechanisms employed by some bacteria, making it a valuable treatment option for a variety of serious infections. However, it should only be used under the guidance and prescription of a healthcare professional.

Benefits of Ceftriaxone & Sulbactam for Injection:

  • Broad-Spectrum Antibiotic: Ceftriaxone & Sulbactam for Injection has a broad spectrum of activity, making it effective against a wide range of bacteria, including Gram-positive and Gram-negative organisms.
  • Beta-Lactamase Inhibition: The inclusion of sulbactam enhances the effectiveness of ceftriaxone by inhibiting beta-lactamase enzymes produced by some bacteria. This allows the medication to remain active against resistant strains.
  • Treatment of Serious Infections: It is particularly valuable in treating severe or complicated infections, including respiratory tract, urinary tract, skin and soft tissue, intra-abdominal, bone and joint, and gynecological infections.
  • Single Daily Dosing: Ceftriaxone has a long half-life, allowing for once-daily dosing, which can improve patient compliance and simplify treatment regimens.
  • Hospital and Clinical Setting Use: It is commonly used in hospitals and clinical settings for treating critically ill patients, making it essential for managing serious infections.

Side Effects of Ceftriaxone & Sulbactam for Injection:

  • Allergic Reactions: Like any antibiotic, Ceftriaxone & Sulbactam for Injection can cause allergic reactions, including rash, itching, swelling, severe dizziness, and difficulty breathing. Seek immediate medical attention if you experience these symptoms.
  • Gastrointestinal Distress: Common side effects may include diarrhea, nausea, vomiting, and abdominal pain. It’s essential to inform your healthcare provider if these symptoms are severe or persistent.
  • Pain or Irritation at the Injection Site: Injection-site pain or redness can occur but is typically mild and temporary.
  • Liver and Kidney Function: In rare cases, Ceftriaxone can affect liver and kidney function. Your healthcare provider may monitor these functions during treatment.
  • Blood Disorders: There may be changes in blood cell counts, including a decrease in white blood cells (neutropenia), which can increase the risk of infections.
  • Prolonged Use: Prolonged or excessive use of Ceftriaxone can lead to the development of antibiotic-resistant bacteria.
  • Clostridium difficile Infection: Antibiotic use can sometimes lead to the overgrowth of a bacterium called Clostridium difficile, causing severe diarrhea and colitis.

It’s crucial to use Ceftriaxone & Sulbactam for Injection only as prescribed by a healthcare professional. If you experience severe side effects or any signs of an allergic reaction, seek immediate medical attention. Your healthcare provider will weigh the benefits of treatment against the potential risks, taking into account your specific medical condition and history. Always follow your healthcare provider’s instructions for the safest and most effective use of this medication.

Frequently Asked Questions About Ceftriaxone & Sulbactam for Injection:

  1. What is Ceftriaxone & Sulbactam for Injection used for?

Ceftriaxone & Sulbactam for Injection is a combination antibiotic used to treat a variety of bacterial infections, including respiratory, urinary tract, skin and soft tissue, intra-abdominal, bone and joint, and gynecological infections. It is especially effective against infections caused by beta-lactamase-producing bacteria.

  1. How is Ceftriaxone & Sulbactam for Injection administered?

This medication is typically administered by healthcare professionals through intravenous (IV) infusion. The dosage and duration of treatment depend on the type and severity of the infection, as well as the patient’s medical condition.

  1. Are there any special precautions to consider during treatment?

Patients should inform their healthcare provider of any allergies, medical conditions, or medications they are currently taking. It is crucial to complete the full course of treatment, even if symptoms improve before the medication is finished, to prevent the development of antibiotic resistance.

  1. What are the common side effects of Ceftriaxone & Sulbactam for Injection?

Common side effects may include diarrhea, nausea, vomiting, abdominal pain, and mild irritation at the injection site. Serious allergic reactions are rare but possible. If you experience severe diarrhea or signs of an allergic reaction (such as rash, swelling, or difficulty breathing), seek immediate medical attention.

  1. Can Ceftriaxone & Sulbactam for Injection be used during pregnancy and breastfeeding?

The use of this medication during pregnancy should be discussed with a healthcare provider, as it can cross the placenta. It is also excreted in breast milk, so the risks and benefits should be carefully considered for breastfeeding mothers.

  1. Can this medication interact with other drugs?

Ceftriaxone & Sulbactam for Injection may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. Inform your healthcare provider of all medications, supplements, and herbal products you are taking.

  1. How quickly should I expect to see improvements in my condition?

The time it takes to see improvements in your condition can vary depending on the type and severity of the infection. It’s essential to follow your healthcare provider’s instructions and complete the full course of treatment for the best results.

  1. What should I do if I miss a dose?

If you miss a dose, contact your healthcare provider or healthcare facility as soon as possible to schedule the missed dose. Do not double the dose to make up for a missed one.

  1. Can I drink alcohol while taking Ceftriaxone & Sulbactam for Injection?

It is generally advisable to avoid alcohol while taking antibiotics. Alcohol can potentially interact with medications and may exacerbate certain side effects.

  1. Is it safe to drive or operate heavy machinery while using this medication?

Ceftriaxone & Sulbactam for Injection is unlikely to impair your ability to drive or operate heavy machinery. However, if you experience dizziness or other side effects that affect your coordination, it is best to avoid such activities until you feel well enough to do so safely.

Always consult with your healthcare provider or pharmacist for personalized information and guidance regarding your specific situation and treatment with Ceftriaxone & Sulbactam for Injection.

As Ceftriaxone & Sulbactam for Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Ceftriaxone & Sulbactam for Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Ceftriaxone & Sulbactam for Injection Regulatory Documents:

  • Certificate of Analysis (COA)
  • Method of Analysis (MOA)
  • Stability Data (Accelerated stability / Long-term stability / Zone 4b)
  • CTD Dossier / ACTD Dossiers / eCTD Dossiers
  • Certificate of Pharmaceuticals Product (COPP)
  • Free Sale Certificate (FSC)
Contact the most reliable manufacturer of Ceftriaxone & Sulbactam for Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593
Fax No: +91 22 2634 1274

GENERIC NAME OF MEDICINAL PRODUCT:

(A) Ceftriaxone & Sulbactam for Injection 1.5gm
(B) Ceftriaxone & Sulbactam for Injection 750mg
(C) Ceftriaxone & Sulbactam for Injection 375mg
(D) Ceftriaxone & Sulbactam for Injection 187.5mg

QUALITATIVE AND QUANTITATIVE COMPOSITION:

1. Ceftriaxone & Sulbactam for Injection 1.5gm
A. Each vial contains:
Ceftriaxone Sodium IP (Sterile)
Eq. to Anhydrous Ceftriaxone …………1000mg
Sulbactam Sodium IP (Sterile)
Eq. to Anhydrous Sulbactam …………500mg
B. Sterile water for Injection IP ……….……… 10ml


2. Ceftriaxone & Sulbactam for Injection 750mg
A. Each vial contains:
Ceftriaxone Sodium IP (Sterile)
Eq. to Anhydrous Ceftriaxone …………500mg
Sulbactam Sodium IP (Sterile)
Eq. to Anhydrous Sulbactam …………250mg
B. Sterile water for Injection IP ……….………10ml

3. Ceftriaxone & Sulbactam for Injection 375mg
A. Each vial contains:
Ceftriaxone Sodium IP (Sterile)
Eq. to Anhydrous Ceftriaxone …………250mg
Sulbactam Sodium IP (Sterile)
Eq. to Anhydrous Sulbactam …………125mg
B. Sterile water for Injection IP ……….………5ml

4. Ceftriaxone & Sulbactam for Injection 187.5mg
A. Each vial contains:
Ceftriaxone Sodium IP (Sterile)
Eq. to Anhydrous Ceftriaxone …………125mg
Sulbactam Sodium IP (Sterile)
Eq. to Anhydrous Sulbactam …………62.5mg
B. Sterile water for Injection IP ……….………5ml

THERAPEUTIC INDICATION:

Ceftriaxone & Sulbactam for Injection is indicated in Sepsis, Meningitis, Abdominal Infections, infections of the Bones, Joints, Soft tissue, Skin and of wounds, Renal and Urinary Tract Infections, Respiratory tract Infections, particularly Pneumonia, and Ear, Nose and Throat Infections, and uncomplicated gonorrhea.

DIRECTION OF USE:

Reconstitute with 10 ml of Sterile Water for Injection IP supplied with pack as required.
Prick the ampoule of Sterile Water for Injection IP only once and discard the unused portion.
Reconstituted solution should be use immediately after preparation.

CAUTION AND SCHEDULE:

CAUTION: If any foreign particle is visible in the vial after dissolving the contents, please do not use the solution.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.
SCHEDULE: SCHEDULE 'H1' DRUG:
-It is dangerous to take this preparation except in accordance with the medical advice.
-Not to be sold by retail without the prescription of Registered Medical Practitioner.
KEEP OUT OF REACH OF CHILDREN.
*Not to be sold without water for Injection.

STORAGE AND DOSAGE:

STORAGE: Store Below 25°C.
Protect from light & moisture.
Do not freeze.
DOSAGE: As directed by Physician.
Note: Water for Injection IP Ampoule is not manufactured by us.