Cefoperazone & Sulbactam for Injection 1gm

Cefoperazone & Sulbactam for Injection 1gm Technical Specification:

GENERIC NAME OF MEDICINAL PRODUCT:

• Cefoperazone & Sulbactam for Injection 1gm

QUALITATIVE AND QUANTITATIVE COMPOSITION:

• Cefoperazone & Sulbactam for Injection 1gm
  Each vial contains:
  Cefoperazone Sodium IP (Sterile)
  Equivalent to Anhydrous Cefoperazone …………. 500mg
  Sulbactam Sodium IP (Sterile)
  Equivalent to Anhydrous Sulbactam………………….. 500mg
  Sterile Water for Injection IP…….10ml

THERAPEUTIC INDICATION:

Cefoperazone +Sulbactam is used in the treatment of bacterial infections. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria.

DIRECTION OF USE:

Dissolve the content of the vial in Sterile Water for Injection IP included in this pack. Reconstitution is to be carried out as per the instruction in the package. Use a reconstituted solution if it is clear and devoid of particulate matter.

CAUTION AND SCHEDULE:

CAUTION: If any foreign particle is visible in the vial after dissolving the contents, please do not use the solution.
FLIP-OFF SEAL IS PROVIDED FOR TAMPER EVIDENCE.
SCHEDULE: SCHEDULE ‘H1’ DRUG; It is dangerous to take this preparation except in accordance with medical advice.
Not to be sold by retail without the prescription of a Registered Medical Practitioner.

STORAGE AND DOSAGE:

STORAGE: Store Below 30°C.Protect from light and moisture. Do not freeze.
The reconstituted solution should be used immediately after preparation.
KEEP OUT OF REACH OF CHILDREN
DOSAGE: As directed by the Physician

Why Taj pharmaceuticals?

Taj Pharmaceuticals is your dependable supplier of Cefoperazone & Sulbactam for Injection, a vital combination antibiotic used to combat serious infections effectively. With our unwavering commitment to pharmaceutical excellence, stringent quality control measures, and a patient-centric approach, we stand as a trusted provider of healthcare solutions. Our dedication to patient well-being ensures that Cefoperazone & Sulbactam for Injection meets the highest international standards of safety and efficacy. We prioritize accessibility to essential medications, ensuring that healthcare providers have access to reliable infection management options when needed most. At Taj Pharmaceuticals, we understand the critical role that Cefoperazone & Sulbactam play in treating serious bacterial infections. Our commitment to quality and safety drives us to provide high-quality antibiotics that healthcare professionals can rely on for precise and effective infection control. Choose Taj Pharmaceuticals for Cefoperazone & Sulbactam for Injection, and experience pharmaceutical expertise that prioritizes your health and the well-being of your patients. We are dedicated to contributing to improved healthcare outcomes by delivering quality medications that make a difference in infection management and patient care. Trust Taj Pharmaceuticals for all your pharmaceutical needs and partner with us in your journey to better health.

Cefoperazone & Sulbactam for Injection is a combination medication used to treat a variety of serious bacterial infections. It consists of two active ingredients:

• Cefoperazone: This is a third-generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. It is effective against a wide range of Gram-positive and Gram-negative bacteria.
• Sulbactam: Sulbactam is a beta-lactamase inhibitor. It does not have significant antibacterial activity on its own but is combined with antibiotics like cefoperazone to extend their spectrum of action by inhibiting bacterial beta-lactamases, which are enzymes that can render antibiotics ineffective.

Uses: Cefoperazone & Sulbactam for Injection is prescribed by healthcare providers for the treatment of various infections, including:

• Intra-Abdominal Infections: It is used to treat intra-abdominal infections, such as peritonitis (inflammation of the abdominal lining) and abscesses.
• Respiratory Tract Infections: It may be prescribed for severe respiratory tract infections like pneumonia and lung abscesses.
• Urinary Tract Infections (UTIs): Cefoperazone & Sulbactam can be effective against complicated UTIs.
• Skin and Soft Tissue Infections: It is used for skin and soft tissue infections, such as cellulitis and wound infections.
• Gynecological Infections: It may be used for infections of the female reproductive system, such as pelvic inflammatory disease (PID).
• Infections in Immunocompromised Patients: Cefoperazone & Sulbactam can be considered for infections in patients with weakened immune systems.
• Other Serious Infections: In some cases, it may be used for infections that have not responded to other antibiotics or for polymicrobial infections where a combination of broad-spectrum antibiotics is needed.

It’s important to note that this medication should only be used under the guidance and prescription of a healthcare professional. The choice of antibiotic therapy depends on the type of infection, its severity, and the susceptibility of the causative bacteria to the medication. Treatment should be completed as prescribed, even if symptoms improve before the full course is finished, to ensure complete eradication of the infection and prevent the development of antibiotic resistance.

How do Cefoperazone & Sulbactam for Injection work?

Cefoperazone & Sulbactam for Injection is a combination medication that works through two mechanisms to combat bacterial infections:

• Cefoperazone (Cephalosporin Antibiotic):
  Cefoperazone is a third generation cephalosporin antibiotic. It works by inhibiting the synthesis of the bacterial cell wall, a crucial structure that provides strength and protection to the bacterial cell. Cefoperazone does this by binding to specific proteins called penicillin binding proteins (PBPs) located on the bacterial cell membrane.
  When Cefoperazone binds to PBPs, it interferes with the crosslinking of the cell wall components, including peptidoglycan. This disruption weakens the cell wall, making it more susceptible to damage and ultimately leading to the death of the bacterial cell.
  Cefoperazone has a broad spectrum of activity, meaning it can target a wide range of both Gram-positive and Gram-negative bacteria.
• Sulbactam (Beta Lactamase Inhibitor):
  Sulbactam is a beta lactamase inhibitor. Beta lactamases are enzymes produced by some bacteria that can destroy or inactivate beta lactam antibiotics, including cephalosporins like Cefoperazone. These enzymes are a common mechanism of antibiotic resistance in bacteria.
  Sulbactam works by irreversibly binding to beta lactamases, rendering them inactive. When administered alongside Cefoperazone, Sulbactam protects the antibiotic from degradation by beta lactamases produced by certain bacteria.
  By inhibiting beta lactamases, Sulbactam extends the antibacterial activity of Cefoperazone, allowing it to remain effective against bacteria that would otherwise have developed resistance to the antibiotic.

In summary, the combination of Cefoperazone and Sulbactam in this medication allows for enhanced antibacterial activity by targeting the bacterial cell wall and protecting the cephalosporin antibiotic from degradation by betalactamase enzymes. This dual mechanism makes Cefoperazone & Sulbactam for Injection effective against a broad spectrum of bacterial infections, including those caused by beta-lactamase-producing bacteria.

Benefits of Cefoperazone & Sulbactam for Injection:

• Effective Treatment: This combination medication is effective against a wide range of bacterial infections, making it a valuable tool for healthcare providers in managing serious infections.
• Broad Spectrum: Cefoperazone has a broad spectrum of antibacterial activity, allowing it to target both Gram-positive and Gram-negative bacteria. Sulbactam, the beta-lactamase inhibitor, extends this spectrum by protecting the antibiotic from enzyme degradation.
• Synergistic Action: The combination of Cefoperazone and Sulbactam works synergistically to combat infections. Sulbactam inhibits beta-lactamases, enhancing the effectiveness of Cefoperazone against resistant bacteria.
• Treatment of Complicated Infections: It is particularly useful in treating complicated infections such as intra-abdominal infections, respiratory tract infections, and skin and soft tissue infections.
• Choice for Resistant Bacteria: In cases where bacteria have developed resistance to other antibiotics, Cefoperazone & Sulbactam may still be effective due to its dual mechanism of action.

Side Effects of Cefoperazone & Sulbactam for Injection:

• Allergic Reactions: As with any antibiotic, allergic reactions are possible. Signs may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if any of these symptoms occur.
• Gastrointestinal Issues: Common side effects include nausea, vomiting, diarrhea, and abdominal pain. These symptoms are generally mild and resolve on their own in most cases.
• Injection Site Reactions: Pain, redness, or swelling at the injection site may occur.
• Liver Function Changes: Cefoperazone & Sulbactam may lead to transient increases in liver enzyme levels in some individuals.
• Kidney Function Changes: In rare cases, it can cause kidney function changes. Monitoring of kidney function is typically done during treatment.
• Blood Disorders: Prolonged use of antibiotics like Cefoperazone can affect blood cell counts, leading to conditions like leukopenia (low white blood cell count) or thrombocytopenia (low platelet count).
• Clostridium difficile Infection: Prolonged use can increase the risk of developing Clostridium difficile-associated diarrhea, a severe intestinal condition.
• Neurological Symptoms: Rarely, patients may experience neurological symptoms like confusion, hallucinations, or seizures.
• Superinfections: Prolonged or inappropriate use of antibiotics can lead to superinfections caused by drug-resistant bacteria or fungi.
• Pain and Inflammation at Injection Site: Pain, inflammation, and irritation at the injection site can occur, but these are generally mild and transient.

It’s important to note that the benefits of Cefoperazone & Sulbactam often outweigh the potential side effects when used to treat serious infections. Healthcare providers carefully consider the appropriateness of this medication based on the specific infection, the causative bacteria, and the patient’s medical history. Patients should report any unusual or severe side effects to their healthcare provider promptly.

Frequently Asked Questions About Cefoperazone & Sulbactam for Injection:

Certainly, here are some frequently asked questions (FAQs) about Cefoperazone & Sulbactam for Injection:

1. What is Cefoperazone & Sulbactam for Injection used for?

Cefoperazone & Sulbactam for Injection is used to treat a wide range of bacterial infections, including intraabdominal infections, respiratory tract infections, and skin and soft tissue infections.

2. How does Cefoperazone & Sulbactam work?

Cefoperazone is an antibiotic that inhibits bacterial cell wall synthesis, while Sulbactam is a betalactamase inhibitor that protects Cefoperazone from enzymatic degradation, enhancing its effectiveness against resistant bacteria.

3. Is Cefoperazone & Sulbactam effective against all types of bacteria?

While it has a broad spectrum of activity, it may not be effective against bacteria that are inherently resistant or have developed resistance mechanisms. It is crucial to perform bacterial cultures and sensitivity testing to determine the most appropriate antibiotic treatment.

4. What are the common side effects of Cefoperazone & Sulbactam for Injection?

Common side effects may include nausea, vomiting, diarrhea, and injection site reactions. More serious side effects are rare but can occur.

5. Can Cefoperazone & Sulbactam be used during pregnancy or breastfeeding?

It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is generally considered compatible with breastfeeding, but a healthcare provider should be consulted.

6. How is Cefoperazone & Sulbactam administered?

It is usually administered by healthcare professionals through intravenous (IV) infusion. The dosage and duration of treatment depend on the type and severity of the infection.

7. Can it be used to treat viral infections like the common cold or flu?

No, it is an antibiotic used specifically for bacterial infections. It is not effective against viral infections like the common cold or flu.

8. What precautions should be taken when using Cefoperazone & Sulbactam?

It should be used with caution in patients with known allergies to cephalosporins or penicillins. Patients should inform their healthcare provider of any allergies or medical conditions before starting treatment.

9. Can Cefoperazone & Sulbactam interact with other medications?

It may interact with other medications, including anticoagulants and certain vaccines. It’s important to inform the healthcare provider of all medications and supplements being taken.

10. Is it available in oral form?

Cefoperazone & Sulbactam is primarily available for intravenous use. There may be oral formulations available in some regions, but this varies by country and availability.

Patients should always follow their healthcare provider’s instructions regarding the use of Cefoperazone & Sulbactam, and any questions or concerns about the medication should be discussed with a healthcare professional.

As Cefoperazone & Sulbactam for Injection Exporters; We can cater to export business queries from the following geographies. We are exporting our Cefoperazone & Sulbactam for Injection product in the Following Countries-

Russia and CIS Countries: Azerbaijan, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Turkmenistan, Uzbekistan and Ukraine

GCC/ Middle East Countries: Saudi Arabia, Yemen, Oman, Bahrain, UAE, Lebanon, Jordan, and Iraq.

African Countries: Nigeria, Tanzania, Sudan, Zambia, Benin, Angola, Liberia

Southeast Asia: Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam, Brunei Darussalam

Other Asian Countries: Nepal, Myanmar, Malaysia, Cambodia, Bhutan, Sri Lanka, Mauritius

Cefoperazone & Sulbactam for Injection Regulatory Documents:

• Certificate of Analysis (COA)
• Method of Analysis (MOA)
• Stability Data (Accelerated stability / Long-term stability / Zone 4b)
• CTD Dossier / ACTD Dossiers / eCTD Dossiers
• Certificate of Pharmaceuticals Product (COPP)
• Free Sale Certificate (FSC)

Contact the most reliable manufacturer of Cefoperazone & Sulbactam for Injection, Taj Pharmaceuticals Limited, to get bulk quantities at a reasonable price.

To Place Orders:

Direct line: +91 8448 444 095 / WhatsApp +91 74 0000 9975 / 74 0000 9976
E-Mail: info@tajpharma.com 
Toll free: 1-800-222-434 / Toll free: 1-800-222-825
General EPA BX: +91 22 2637 4592 / +91 22 2637 4593