Pemetrexed for Injection 500mg (Actoforan) – Leading Manufacturer, Supplier and PCD Pharma Franchise Provider in India
Taj Pharmaceuticals Ltd. is a premier name in the Indian pharmaceutical landscape, widely acclaimed as the leading manufacturer, supplier, and exporter of Pemetrexed for Injection 500mg (Actoforan). With state-of-the-art manufacturing facilities in Vapi, Gujarat, and a strong operational base in Mumbai, Maharashtra, we provide a seamless supply chain of oncology drugs across India, Africa, the Middle East, CIS, LATAM, and beyond.
Our formulation of Pemetrexed for Injection 500mg, marketed under the brand name Actoforan, is trusted by healthcare professionals and institutions across PAN India and international markets for its efficacy, quality, affordability, and compliance with global regulatory standards.
Pemetrexed for Injection 500mg (Actoforan): An Overview
Pemetrexed for Injection is a broad-spectrum antifolate chemotherapy agent primarily used for the treatment of:
- Non-Small Cell Lung Cancer (NSCLC)
- Malignant Pleural Mesothelioma
Actoforan 500mg is a lyophilized powder that is reconstituted and administered intravenously. Its mechanism of action involves the inhibition of enzymes essential for DNA and RNA synthesis, thereby blocking the growth and multiplication of cancer cells.
Why Choose Taj Pharma for Pemetrexed Injection 500mg?
1. Certified Manufacturing Facilities
- WHO-GMP and EU-GMP Certified Plants
- Compliance with ICH, PIC/S, and FDA standards
- Ultra-modern lyophilization, sterile filling, and automated packaging lines
2. PAN India and Global Export
We offer nationwide delivery and export to over 40+ countries, including Nigeria, Kenya, Iraq, UAE, Vietnam, Brazil, and Peru, backed by proper documentation: COA, FSC, COPP, MSDS, and Dossiers (CTD format).
3. End-to-End PCD Franchise Support
Taj Pharma extends PCD Pharma Franchise opportunities for Pemetrexed Injection 500mg, enabling pharma professionals, entrepreneurs, and distributors to market oncology products under monopoly rights with complete promotional and marketing support.
Pemetrexed Injection 500mg – Composition and Formulation Details
- Brand Name: Actoforan
- Generic Name: Pemetrexed Disodium Hemipentahydrate
- Strength: 500 mg per vial
- Form: Lyophilized Powder for Injection
- Route of Administration: Intravenous (IV) Infusion
- Appearance: White to pale yellow powder in a sterile glass vial
- Packaging: One vial per carton with insert leaflet
- Storage: Store below 25°C. Protect from light. Do not freeze.
Therapeutic Indications of Pemetrexed Injection
Actoforan 500mg is approved and recommended for use in:
- First-line treatment of Non-Squamous NSCLC in combination with cisplatin
- Second-line monotherapy for locally advanced or metastatic NSCLC after prior chemotherapy
- First-line treatment of unresectable Malignant Pleural Mesothelioma with cisplatin
- Maintenance therapy following induction with platinum-based chemotherapy
Mechanism of Action
Pemetrexed inhibits folate-dependent enzymes such as:
- Thymidylate Synthase (TS)
- Dihydrofolate Reductase (DHFR)
- Glycinamide Ribonucleotide Formyltransferase (GARFT)
By targeting these critical enzymes, Pemetrexed blocks the formation of nucleotides essential for DNA replication, thus hindering tumor cell growth and inducing apoptosis.
Dosage Guidelines
- Recommended dosage: 500 mg/m² of body surface area
- Administered once every 21-day cycle
- Must be reconstituted with sterile 0.9% sodium chloride and infused over 10 minutes
- Co-administration with folic acid and vitamin B12 is advised to reduce hematologic and GI toxicity
- Dexamethasone is administered to prevent skin rash
Dosage modifications are necessary based on toxicity profile and renal function.
Adverse Effects and Safety Measures
While Actoforan (Pemetrexed 500mg) is generally well tolerated, some commonly observed side effects include:
- Neutropenia, thrombocytopenia, and anemia
- Nausea, vomiting, diarrhea, and loss of appetite
- Mucositis or stomatitis
- Fatigue, rash, and hair loss
- Peripheral neuropathy in prolonged usage
Precautions:
- Avoid during pregnancy and lactation
- Effective contraception must be used during and post-treatment
- Monitor CBC, liver and kidney function, before and during treatment
- Inform doctors immediately in case of fever, sore throat, or unusual bleeding
Pemetrexed Injection Manufacturer & Exporter in Mumbai, Maharashtra
As one of the top oncology manufacturers in Mumbai, Taj Pharma ensures seamless coordination between manufacturing, warehousing, and distribution hubs for uninterrupted supplies across Maharashtra and other Indian states.
Our Mumbai office serves as the export coordination center handling documentation, regulatory queries, and logistics for international buyers.
Pemetrexed Injection 500mg PAN India Distribution
We ensure rapid and reliable supply of Actoforan 500mg across all Indian states including:
- Delhi NCR
- Bangalore, Karnataka
- Hyderabad, Telangana
- Chennai, Tamil Nadu
- Lucknow, Uttar Pradesh
- Ahmedabad, Gujarat
- Kolkata, West Bengal
Best Price Guarantee
We understand the burden of oncology treatment costs, and hence Taj Pharma assures competitive pricing of Pemetrexed Injection 500mg without compromising on purity, stability, or therapeutic performance.
Bulk purchase options and distributor pricing are available upon request. Our transparent pricing model ensures affordability and accessibility across all sectors, including hospitals, NGOs, and government institutions.
Documents & Regulatory Support
As a reputed global manufacturer, we provide full support in the form of:
- Certificate of Pharmaceutical Product (COPP)
- Certificate of Analysis (COA)
- Good Manufacturing Practice (GMP) Certificate
- Drug Master File (DMF) / Dossier (CTD/eCTD)
- MSDS (Material Safety Data Sheet)
- Third-party Audit Reports (if required)
PCD Pharma Franchise – Oncology Segment
We invite applications for PCD Pharma Franchise for Pemetrexed Injection 500mg and other oncology products. Our franchise partners enjoy:
- Monopoly Rights for Territory
- Product Training & Literature
- Visual Aids & Promotional Gifts
- 24×7 Distributor Support
- Timely Dispatches & Stock Availability
Taj Pharma ensures mutual growth and long-term business partnerships for all stakeholders.
Connect with Taj Pharma – Your Oncology Partner
Whether you’re a hospital buyer, distributor, PCD franchise partner, or international importer, Taj Pharma is your reliable manufacturer and supplier for Pemetrexed Injection 500mg (Actoforan).
📞 Call/WhatsApp: +91 84484 44095
📧 Email: info@tajpharma.com
🌍 Website: www.tajpharma.com
📍 Manufacturing Unit: Vapi, Gujarat
📍 Corporate Office: Mumbai, Maharashtra
Taj Pharma India is the leading Pemetrexed for Injection 500mg manufacturer, supplier, and PCD Pharma franchise company offering unmatched quality, reliability, and global reach. Trusted by healthcare professionals and institutions across continents, Actoforan continues to set the benchmark for safe and effective cancer care.
